It sucks not being at 100% and pretending to everyone else that we're fine. We've all been there.
It's possible that the mesalamine is causing kidney/renal issues, it is a rare side effect. Discontinuing the mesalamine would eventually return your renal numbers to normal, if it is medication-induced.
Pros and cons to everything. Hard to justify jumping onto biologics when your symptoms are so darn mild, in a way. I don't know which way I'd go, in your case.
Cons for immunomodulators. Are you male? What's your age? I ask as adolescent (a term that many gasteroenteroligists use cautiously for 30-ish or less) males then you do have to consider that with immunomodulators you'd have increased risk of lymphoma. During the initial clinical trials of UC and azathioprine/imuran/6MP, adolescent males were the only ones to have a lymphoma. As such, gasteroenteroligists often don't prescribe to that demographic, or will limit prescribing it to 2-years at most, and then get you off of it. Anything but a certanty of having that problem, just increased risk.
Immunomodulators require frequent bloodwork for everyone on it. Take about
3-months to work. Very, slow acting meds.
Pros, immunomodulators are generic medications, simple oral pills you can take, are overall weaker medications that enable you to save biologics for later (just incase you need them later).
Cons biologics. They are all expensive brand-named medications that require either an IV (at a hospital or infusion-center) to administer or a self-injection to administer.
Pros biologics. No bloodwork required. Very quick working, taking 6-weeks or less in most patients. Infrequent infusions (every 8-weeks with remicade). The top-down approach (that is using the strongest medications earlier) might prevent your UC from spreading in extent or severity, give you the least frequent flares and best quality of life.
Moderator Ulcerative Colitis
John, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasaSevere flares make the common toilet worse than any medieval torture imaginable. The rack? Bah! I survived the thousand razor blade poop for weeks!
Post Edited (iPoop) : 1/2/2018 7:00:33 AM (GMT-7)