Tough call especially with mild symptoms. Is Entyvio an option? This medicine is gut specific so in theory it should not effect the rest of your body like the others. Another thought...with mild symptoms-- if you can continue to use the Salofolk enemas-- (but not oral mesalamine) What about slippery elm, Tumeric or something like that. I don't know if it would be enough especially since you were severe at one point but thought I would throw it out there.
Interesting. I actually tried turmeric for the first month after diagnosis, but decided it wasn't helping.
The thing that most people with IBD have in common is that their immune system is down-regulated or deficient. Most people think that their immune systems are over-active and that's the reason for the crazy inflammatory response, but it's actually that the immune system is dysmodulated (behaving improperly) combined with not being strong enough. It attacks the wrong things and in the wrong proportions, yet it doesn't have strength against things like the common cold.
When immune activity is low, we tend to feel run down. The body becomes less efficient at clearing viruses, bacteria and cellular wastes. The endocrine (hormone) system starts to get slower as well as the over all metabolic state.
I used to feel that malaise a lot and I still do during my recovery periods. Since taking Low Dose Naltrexone, I feel more or less normal. It boosts the immune system and modulates it. However, it doesn't work for everyone. In my first 3 weeks of taking it, I thought I contracted the flu. What actually happened was that my body was getting strong enough to clear out the backlog of stuff it wasn't able to deal with before. After that, I felt great.
Your kidney signs could be a side effect of drugs, or it could be due to a reduced metabolic rate. If you're chronically fatigued and feeling run down most of the time, then your body might be operating at a lower equilibrium. At least, that's what it was for me. When my immune system got stronger I could start exercising more, and when I could do that my kidney function increased. Unless you have actual kidney disease signs, the lowered eGFR could be a sign that the body is tired and slowing down. My eGFR before taking LDN was 65-70, and after it went up to 95 and 100 most of the time. Also keep in mind that kidney tests will be affected by how much protein you consume. If you recently ate meat then your creatinine will be higher which will make your eGFR lower.
Do you know that your blood urea nitrogen level is? (BUN test)
Don't think I've had a BUN test. My eGFR is very similar to yours; I had a single reading with a eGFR of 59 but I'm generally in the mid 60s. No other clinical signs/symptoms (unless tiredness counts). My eGFR was lowish before I started Mesalazine and I personally don't think it's drug related. I've tried all the tricks to make a high GFR reading including drinking loads of water and avoiding all protein - it's consistently lower than when I was younger.
My presenting complaint to my GP before diagnosis was feeling crap/tired all the time rather than GI symptoms funnily enough - these symptoms are still present. Not sure Naltrexone will be supported by my doctor at the moment but it's useful to keep in mind if everything else fails!
Thanks guys. I think I'm going to avoid azathioprine if possible and go for a biologic. I'll do a bit of research tonight about
the different options before my hospital appointment tomorrow! Despite being a doctor, I've read as little as possible about
IBD to keep myself sane
Post Edited (SuperBowser) : 1/3/2018 4:25:03 AM (GMT-7)