Helping your UC with genetics

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Connor77
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Date Joined Jul 2016
Total Posts : 523
   Posted 1/11/2018 5:06 PM (GMT -6)   
I've been doing a lot of research on my own genetic pathways. I know that I may always have UC but my curiosity about the root cause is never ending.

I've been looking at MTHFR, MTR(R), COMT, and other common gene variations.

Have any of you successfully used genetic data to improve your condition? For example, some people have more B12 requirements, some need methyl-B12 instead of other kinds, some have a higher need for antioxidants, some can't make vitamin D effectively...

Because the colon is a waste repository in the body, it makes me wonder if genetic deficiencies can cause a toxin overload, which in turn causes a flare in some people.

Anyway, I am just curious if others have downgraded their condition by following the guidance of their genetic readouts? I'm asking because I'm about to undertake this task, but if it has no real impact for most people then I don't want to waste my time.

If you're willing to share what you found out and what you tried changing in your life or supplementing, I would really love to read about it.

iPoop
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Date Joined Aug 2012
Total Posts : 13220
   Posted 1/11/2018 6:48 PM (GMT -6)   
I had the 23andme genetic testing. They shown nothing about uc in their reports. I downloaded the data and brought it into promethease. It was interesting but nothing I could do anything with.

What did you do for genetic testing? How did you analyze it?
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

A semi-finalist in the Olympic 15-meter bathroom-sprint. Aimed for the gold but just ended up getting brown...

Spring
Regular Member


Date Joined Jan 2017
Total Posts : 395
   Posted 1/11/2018 10:30 PM (GMT -6)   
I am reading a download currently from another thread that talks about what you are asking. I am on my phone so I can't link it right now, but try searching for IBD-Briggs. My brother was not responding to any meds (no insurance for biologics) and very severe. He is in remission now, and he thinks what turned him around was custom minerals given based on hair analysis. He had copper toxicity and Byrillium toxicity, and none of his levels were in the range of normal. I am hoping to try it, but have not gotten the info yet from his distributed.
36yr old mother of 3 Moderate Pancolitis 1/3/17. Hosp 1 week on Solumedrol, Delzicol. Apriso, pred, then switched to Balsazide 750 mg, and Uceris 9 mg 3 wks. Minor flare in August, flare since Oct 20. Acute pancreatitis from Balsalazide hosp. 2 days, Started Humira 12/15/17, 40 mg pred, waiting on Entyvio due to reaction Humira. Veg, gf, no cows milk, multi, cal-mag, Aroga, Purrium

Spring
Regular Member


Date Joined Jan 2017
Total Posts : 395
   Posted 1/11/2018 10:32 PM (GMT -6)   
The article is currently on this page under Old Mike requesting info on Briggs.
36yr old mother of 3 Moderate Pancolitis 1/3/17. Hosp 1 week on Solumedrol, Delzicol. Apriso, pred, then switched to Balsazide 750 mg, and Uceris 9 mg 3 wks. Minor flare in August, flare since Oct 20. Acute pancreatitis from Balsalazide hosp. 2 days, Started Humira 12/15/17, 40 mg pred, waiting on Entyvio due to reaction Humira. Veg, gf, no cows milk, multi, cal-mag, Aroga, Purrium

Connor77
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Date Joined Jul 2016
Total Posts : 523
   Posted 1/12/2018 10:11 PM (GMT -6)   
iPoop, I originally got my genetics done with 23andme, but I plugged the raw data into PureGenomics. They have the best written results and it includes visual diagrams of which portions of the metabolic pathways may be affected.

23andme does do a report for UC. For example I am 2.3x more likely to get it, but even that number is not very high. However, if I consider the detox pathways, then it's another story. I remember reading a study not long ago that talked about how IBD patients often have faulty detoxing pathways, especially MTHFR, MTR(R), and SO2.

If the body can't break down toxins effectively then you'll accumulate them more quickly. More toxins equals more inflammation. All the elimination channels would be overloaded including the liver and colon.

Anyway, my investigations are still preliminary. I was just curious if anyone else had used their genetic info to tailor a protocol that helped them out.
DX left-sided UC 2015, 3 fulminant flares since then
Diagnosed with mycobacterium avium paratuberculosis (MAP) September 2017
Commenced AMAT (rifampin, clarithromycin, clofazimine) November 1 2017
Intolerant to clofazimine, stopped taking
Others: prednisone 10mg, Entyvio every 4 weeks, Low Dose Naltrexone 3mg at bedtime, natural ferments

Connor77
Veteran Member


Date Joined Jul 2016
Total Posts : 523
   Posted 1/12/2018 10:15 PM (GMT -6)   
Spring said...
I am reading a download currently from another thread that talks about what you are asking. I am on my phone so I can't link it right now, but try searching for IBD-Briggs. My brother was not responding to any meds (no insurance for biologics) and very severe. He is in remission now, and he thinks what turned him around was custom minerals given based on hair analysis. He had copper toxicity and Byrillium toxicity, and none of his levels were in the range of normal. I am hoping to try it, but have not gotten the info yet from his distributed.


Thanks for this info, but I'm not really referring to heavy metal toxicity. This is not about environmental poisoning, but the body's innate ability to detox its own waste products. Environmental toxins can add an extra burden and cause flares, but they are not the root of the problem. The root is faulty genetics in metabolic pathways.

If someone has two damaged copies (-/-) of an MTHFR SNP, or MTR, or SO2, then they may only be able to partially break down waste products, causing accumulation in the tissues. This down-regulates the immune system and upgrades inflammation.

What I'm trying to figure out is, for someone with these deficiencies, what would they supplement in order to help themselves?

imagardener2
Veteran Member


Date Joined Jan 2010
Total Posts : 5775
   Posted 1/13/2018 12:48 AM (GMT -6)   
I did 23andme years back there was lots of discussion on this forum about MTHR. If memory serves, my 23andme numbers run through another site said I was half and half on MTHR (if that makes sense, been a while).

Anyway I tried different B-12 supplements and my gut said to cut that stuff out. My history with supplements is not good.

My 23andme report says my genes likely for celiac, tested negative on the blood test but never did the gold standard gut test, just eliminated gluten and that helped. Also likely for Crohn's but not for UC. Go figure, never a word about Crohn's from any GI in 16 years.
Diet=gluten-free modified Paleo+potatoes+low dairy, low grain, no seafood (IBS),low fiber diet
In remission April 2010 after 10 years of UC after no remission ever
gluten-free =bleeding stopped, dairy-free (less IBS) started remission path+food diary
daily: Balsalazide 750mg and 2 Ginkgold tablet
rarely: VSL#3, mesalamine enema, Canasa supp, Citrucel
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