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New Member

Date Joined Mar 2018
Total Posts : 5
   Posted 3/9/2018 2:40 AM (GMT -6)   
I got diagnosed with UC 2 years ago and am now in the middle of my second flare up. I'm taking 4.8 gm of Mesalamine a day, Canasa suppository at bedtime and on high dose prednisone. Labs drawn every week for the last 3 weeks have shown elevated LFT's. Most recent is ALT 187 AST 82. Should this be cause for concern as these numbers continue to increase with every blood draw. My colitis seems to be improving at the moment while on prednisone and I am down to 6 stools a day at present but continually feeling the effects of tiredness and fatigue. Does any one know if increase LFT's is normal during a flare and what it could be caused by?

Forum Moderator

Date Joined Aug 2012
Total Posts : 13246
   Posted 3/9/2018 8:33 AM (GMT -6)   
Have you spoken to your gasteroenteroligist about your raised ALT and AST values? And if so, what did he/she say?

Your ALT and AST values are high and out-of-range, if the range of your tests are similar to mine. I pulled up my most recent LFT test and here are my numbers, for reference.

ALT....39..........21 - 72 U/L
AST....25.........15 - 46 U/L

I did some searching, and prednisone can send these numbers rising. Whether your numbers are normal/expected or a warning sign of potential damage, I am not sure and I would defer to a doctor on that inquiry. "Corticosteroid therapy is associated with several forms of liver injury, some due to exacerbation of an underlying liver disease and some that appear to be caused directly by corticosteroid therapy." Take a look at the "Hepatotoxicity, Mechanism of Injury" section of the link below, and it describes a number of things that could happen.

I'd ask your doctor whether this is something to be worried about or not. I cannot honestly say. I always like to verify and confirm.
Moderator Ulcerative Colitis
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

UC experience: wakeup with noisy bowels so no lingering in bed, soon after poop with discomfort/pain/mild-nausea, eat something, poop, get dressed, poop, leave in car and worry whole drive about more...

Post Edited (iPoop) : 3/9/2018 6:36:44 AM (GMT-7)

Regular Member

Date Joined Jun 2017
Total Posts : 54
   Posted 3/9/2018 8:57 AM (GMT -6)   
I have a son with liver disease and have learned over the years that AST/ALT can and will go up and down for a variety of things. Those values are high and you should ask your doctor about them.

However, I will tell you that our son's liver specialist told us many times values like that are no big deal. Having a cold can cause them go higher that than. They can change drastically from day to day. The trend is more important than a single value.

Follow up with your doc, but for now, not something I would worry too much about.
Gluten Free Celiac
Drug Induced Lupus
Currently taking 3.0 mg LDN daily
Allergy to Lialda
Developed Antibodies to Remicade after 3 months
Insurance hasn't approved anything else. Last dose of Remicade Oct 4, 2017

Veteran Member

Date Joined Sep 2005
Total Posts : 5163
   Posted 3/9/2018 11:43 AM (GMT -6)   
I got numbers like that from Asacol, I was allergic to it and was experiencing a very bad flare. I haven't had bad numbers since

DX'd with Severe Pancolitis June 2005
Previous Meds: 5ASAs, Predisone, 6-MP. Remicade, Humira, Simponi, Cimzia & Cyclosporine
3-step J-Pouch surgery: 2013 & 2014

Current Condition: Chronic Pouchitis -- Not as bad as I thought it would be
Current Meds: Stelara
Total Hip Replacement: 12/16 -- Thanks Prednisone!!!

New Member

Date Joined Mar 2018
Total Posts : 5
   Posted 3/12/2018 2:29 AM (GMT -6)   
Thank you all so much for all your help and insight. Going back on Tues for repeat labs to check LTF's. Prayers appreciated.
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