Have any of you see these science articles???

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Regular Member

Date Joined Aug 2012
Total Posts : 21
   Posted 3/10/2018 8:51 PM (GMT -6)   
This is one:

According to the research in this study, autoimmune disorders are caused by a specific bacterium in the gut. The hope is that they can cure theses diseases with an antibiotic that specifically targets this bacterium.

Hopefully there will be more research to come...quickly.

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Date Joined Jul 2016
Total Posts : 519
   Posted 3/10/2018 9:47 PM (GMT -6)   
IBD is most likely pathogenic in origin, with the immune system being exhausted and dysregulated as a result. There may not be one pathogen but several, and leaky gut along with high histamine are certainly complicating factors.
DX left-sided UC 2015, 3 fulminant flares since then
Started FMT clinical trial Feb 2018
Dx w/mycobacterium avium paratuberculosis (MAP) Sept 2017
Stopped AMAT @ 6 weeks due to intolerance of meds
Others: Entyvio every 4 weeks, Low Dose Naltrexone 3mg at bedtime, natural ferments
Current status: lingering rectal bleeding, otherwise healthy

Canada Mark
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Date Joined Jan 2013
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   Posted 3/10/2018 9:55 PM (GMT -6)   
Hi Judy, thanks for posting.

Not all autoimmune disorders, but the idea in general applies and most likely not just one type of bacteria.

I happened to be lucky and had access to the full study as we have a subscription a work for other non-biology purposes. If it helps or interests anyone, for the vaccine they used heat killed bacteria of the same type that translocated across the intestinal barrier in mice. What's interesting is after vaccination it prevented translocation across the mucosal barrier, but the vaccine had to be specific to this bacteria, not other types of bacteria.

It seems there is some relevance to the MAP Vaccine, Triple ABX an Qu (?) Biologics all in one study. If I read it right treatment with ABX (Vancomycin) resulted in lower autoantibodies and pro-inflammatory T-cells, which corresponded with a decrease in bacteria in the small intestinal tissue.

They make this statement at the end - "Thus, pathobiont-specific treatment can abrogate host autoimmune processes without needing to suppress the immune system, which can lead to systemic adverse events in current clinical practice." Which many will identify with.

The bacteria in the study is E. gallinarum. They then tested tissues samples from people with SLE and autoimmune hepatitis and were able to isolate this particular bacteria from the majority of patients.

In regards to autoimmune they state this:
"Our findings show that the Gram-positive gut pathobiont E. gallinarum translocates, as a result of gut barrier breakdown, into systemic organs in autoimmune-prone hosts to drive autoimmune pathogenesis (fig. S20). Translocating bacteria may not only skew T helper cell differentiation but may also directly act on colonized tissues, such as the liver, to induce autoantigens, ERV proteins, cytokines, and other autoimmune-promoting factors."

The whole thing was really interesting really, but not really easy to understand some aspects.

Anyway, I know in the MAP realm there has been suggestion that bacteria in the blood/lymph can trigger autoimmune reactions, but this is the first study I have read or come across that demonstrates the issue and follows it up with finding bacteria in people (patients with SLE and autoimmune hepatitis).

I guess they stopped short of trying to treat the human patients so who knows really, but maybe they will at some point soon. Would be amazing to see these people get better if it's possible.
Diagnosed Crohns-Colitis 12-13 years ago - Past Meds: Antibiotics, Prednisone, Methotrexate, Imuran, Remicade - Current Meds: Imuran 150mg/daily, Natural: WOO/Thyme Oil, All organic food no additives as best as possible. I stopped taking probiotics as I felt they were not helping much.

“The only person you're destined to become, is the person you decide to be"

Veteran Member

Date Joined Dec 2006
Total Posts : 931
   Posted 3/10/2018 10:29 PM (GMT -6)   
Interesting! Thanks for posting.
DX Pancolitis 2003. Subsequent flares limited mostly to left side
Flare every 2-3 years that is bad enough to require Pred.
9x Salofalk tabs, Sulfa free Rowasa nightly and Canasa each morning
Probiotics: None Fiber: Psyllium.

Been in remission for the last 3 years.

Uniform Charlie
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Date Joined Jul 2015
Total Posts : 622
   Posted 3/12/2018 7:30 AM (GMT -6)   
Thanks for sharing judyjo.

Canada Mark, you have been studying IBD for a while...do you ever remember a time when so much research was going into IBD and autoimmunity? I've only been around for 2+ years and the progress in available info in that short time has been amazing, but maybe I just wasn't looking in the right places before.

The MAP stuff coming out is interesting in regards to Crohn's and just recently a link to Rheumatoid Arthritis.
Diagnosed Proctosigmoiditis (UC) February 2015
Current Meds: Lialda 1.2gm 2x daily, duloxetine, rowasa as needed, Curcumin, VSL3 occasionally, One a Day Multi-Vitamin
Did SCD for about 2 years but lost willpower. Want to get back to it at some point.

Regular Member

Date Joined Aug 2012
Total Posts : 21
   Posted 3/12/2018 7:47 AM (GMT -6)   
Thanks for the help at understanding this Canada Mark. Hope more research info is released to help us all keep up with this development.
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