OT: Do antidepressants work?

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IamCurious
Veteran Member


Date Joined Jan 2010
Total Posts : 3180
   Posted 3/12/2018 6:26 AM (GMT -6)   
The most comprehensive study on them has recently been published, showing mostly modest effects.

https://www.nytimes.com/2018/03/12/upshot/do-antidepressants-work.html?module=WatchingPortal®ion=c-column-middle-span-region&pgType=Homepage&action=click&mediaId=thumb_square&state=standard&contentPlacement=2&version=internal&contentCollection=www.nytimes.com&contentId=https%3A%2F%2Fwww.nytimes.com%2F2018%2F03%2F12%2Fupshot%2Fdo-antidepressants-work.html&eventName=Watching-article-click


"The researchers found 74 studies, with more than 12,500 patients, for drugs approved between 1987 and 2004. about half of these trials had “positive” results, in that the antidepressant performed better than a placebo; the other half were “negative.” But if you looked only in the published literature, you’d get a much different picture. Nearly all of the positive studies are there. Only three of the negative studies appear in the literature as negative. Twenty-two were never published, and 11 were published but repackaged so that they appeared positive.

"The take-home message from these two studies was that the effectiveness of antidepressants had been overstated, and that the benefit might be limited to far fewer patients than were actually using the drugs.

"The benefits also applied only to people who were suffering from major depression, specifically in the short term. In other words, this study provides evidence that when people are found to have acute major depression, treatment with antidepressants works to improve outcomes in the first two months of therapy."

quincy
Elite Member


Date Joined May 2003
Total Posts : 30596
   Posted 3/12/2018 11:37 AM (GMT -6)   
Made a live link, but don't know how to make it shorter so that it doesn't go across the whole page.

Not all who use antidepressants are on the right ones...trial and error, and many are not in therapy.
What I use is enough to take the edge off....but I'm always aware of the depression.

Do they work is subjective on many aspects.....it also depends on what one expects and what one understands about having it.
q

/www.nytimes.com/2018/03/12/upshot/do-antidepressants-work.html?module=WatchingPortal®ion=c-column-middle-span-region&pgType=Homepage&action=click&mediaId=thumb_square&state=standard&contentPlacement=2&version=internal&contentCollection=www.nytimes.com&contentId=https%3A%2F%2Fwww.nytimes.com%2F2018%2F03%2F12%2Fupshot%2Fdo-antidepressants-work.html&eventName=Watching-article-click
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma); Effexor XR 75mg (depression); Rosuvastatin 10mg (cholesterol); Telemesartin 80mg / Amlodipine 5mg (BP)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care + Genuine Health Advanced Gut Health 15 billion @ bedtime)
~Metamucil capsules 6 @ 2x daily with meals; Vitamin D 4500 IU
~URSO 500mg @ 2x daily for Primary Biliary Cholangitis
"TREAT (FROM)BOTH ENDS" worth it !!

Post Edited (quincy) : 3/12/2018 11:43:39 AM (GMT-6)


eekseel
Regular Member


Date Joined Apr 2017
Total Posts : 110
   Posted 3/12/2018 11:46 AM (GMT -6)   
Although I agree, how exactly does this relate to UC?
Diagnosed UC 2009 - Moderate Pancolitis since 2015.
April 2017 stopped Lialda after 5 years, in remission after 6 months Qing Dai (3grams daily) + 60mg sulforaphane (140g brocolli sprouts, juiced) + good multivitamin, fish oil, CBD oil, cardio and other odds and ends.

You can only lead a horse to water...

Uniform Charlie
Veteran Member


Date Joined Jul 2015
Total Posts : 698
   Posted 3/12/2018 12:14 PM (GMT -6)   
@eekseel, that's what OT means in the subject heading..."outside topic."

It is semi-relavent because many people with UC (and other chronic diseases) deal with depression. There have been several discussions here on HW about people using antidepressants and seeing an improvement in UC symptoms. The CCFA is doing a study on this now through their research partner, "IBD partners."

I have read similar studies that show cognitive behavioral therapy to be equally, if not more effective than anti-depressant medications for certain types of depression.
Diagnosed Proctosigmoiditis (UC) February 2015
Current Meds: Lialda 1.2gm 2x daily, duloxetine, rowasa as needed, Curcumin, VSL3 occasionally, One a Day Multi-Vitamin
Did SCD for about 2 years but lost willpower. Want to get back to it at some point.

countess18
Regular Member


Date Joined May 2016
Total Posts : 232
   Posted 3/12/2018 12:40 PM (GMT -6)   
I am in CBT with a psychologist and have started Mirtazapine this year. I have always been an anxious person but this disease and maybe some of the meds have caused a real depression. Even on the Mirtazapine I feel kind of depressed. It takes away the anxiety but not all of it. I can say that CBT has helped some but it feels more like a physiologic depression that is out of my control. I have come off of prednisone a week ago so maybe that adds to it. I think when my body/GI system feels at peace then I feel at peace not the other way around. My psych doctor told me that when the GI system is off kilter then it can directly affect our well being. I'm supposedly in remission right now but don't feel elated.... not sure why.
Thanks

T
diagnosed proctitis April 2016 s/p a c diff infection age 53
Nov 2017- ?Crohns colitis to mid transverse - mild/moderate
remission March-Sept 2017 then flared again-failed prednisone wean
started Humira 11/17/17, off prednisone since 12/26, balsalazide 3/ 3x day cannot tolerate Lialda or probiotics
past meds- cortifoam, canasa, rowasa, plan is -will be off all meds except Humira

TroubledTurds
Veteran Member


Date Joined Jan 2004
Total Posts : 8335
   Posted 3/12/2018 1:07 PM (GMT -6)   
different strokes for different blokes - like most everything else, having more options is more better - while i'm never a real advocate for drugs, certainly there are situations where they are a viable pursuit, and sometimes about the only choice -

do they always work ? hell no - but then what does ?
dx'd with pancolitis 12/21/03
current supplements:vit D, vit K2, cal/mag - grain free/paleoish diet that includes 100% grass fed beef, raw goat milk, & local organic free range eggs, lots of all natural well water, exercise, sleep as much as possible & enjoy this great life that God has blessed me with !

suchatravesty
Regular Member


Date Joined Dec 2017
Total Posts : 168
   Posted 3/12/2018 2:50 PM (GMT -6)   
Mine work. I know what I was like before, and I know what I am like now, and I know what happens when I stop taking them.
Left-sided colitis dx on 12/28/17, with concurrent onset of chronic hives & food allergies (wheat, peppers).

4.8g Lialda (1 month) Budesonide 9mg (3 weeks) Prednisone
Saccharomyces Boulardii 2x/day
40mg Zyrtec, 300mg Zantac & Singular for the hives
20mg citolopram for depression
500mg metaformin for PCOS

Connor77
Veteran Member


Date Joined Jul 2016
Total Posts : 523
   Posted 3/12/2018 3:59 PM (GMT -6)   
When it comes to UC, I think anti-depressants are only symptom management. This disease is destabilizing to the neurochemistry, and it's traumatic on top of it. If your symptoms of depression are severe it could be good to try anti-depressants to get you relief, even if it doesn't affect your UC.

I've been reading a lot about this meta analysis. The consensus seems to be that most anti-depressants are better for short term rather than long-term intervention at 6 months or less.
DX left-sided UC 2015, 3 fulminant flares since then
Started FMT clinical trial Feb 2018
Dx w/mycobacterium avium paratuberculosis (MAP) Sept 2017
Stopped AMAT @ 6 weeks due to intolerance of meds
Others: Entyvio every 4 weeks, Low Dose Naltrexone 3mg at bedtime, natural ferments
Current status: lingering rectal bleeding, otherwise healthy

quincy
Elite Member


Date Joined May 2003
Total Posts : 30596
   Posted 3/13/2018 11:28 AM (GMT -6)   
Connor....you don't have depression, do you?
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma); Effexor XR 75mg (depression); Rosuvastatin 10mg (cholesterol); Telemesartin 80mg / Amlodipine 5mg (BP)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care + Genuine Health Advanced Gut Health 15 billion @ bedtime)
~Metamucil capsules 6 @ 2x daily with meals; Vitamin D 4500 IU
~URSO 500mg @ 2x daily for Primary Biliary Cholangitis
"TREAT (FROM)BOTH ENDS" worth it !!

Hambo88
New Member


Date Joined Feb 2018
Total Posts : 14
   Posted 3/14/2018 4:32 AM (GMT -6)   
For me wellbutrin working for very well.
But i dont use it because it cause me anxiety.
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