How much medicine is too much?

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Date Joined Aug 2012
Total Posts : 12526
   Posted 6/13/2018 1:49 PM (GMT -6)   
All biologics have a response rate of about 65%, meaning you receive a positive improvement from the medication and your UC symptoms improve as a result thereof. Remission rates are low-to-mid 30%, within 6-months to 1-year (the maximum study time due to budget constraints of running multi-year studies). Meaning some still might achieve a remission from the med after the study period ended (I was darn close to a year for a full remission, might've been just a hair over it).

Immunomodulators (imuran/6mp/azathioprine)have a 65-70% response rate.

Mesalamines have a 65-70% response rate as well.

In the end, there's a stubborn 25-35% of us that do not respond to anything within a clinical study. It's possible that a percentage of that stubborn group might respond to combination-therapy (studies cover only one drug at-a-time). That is take, mesalamine, immunomodulars, and biologics all at once and achieve a remission. Some just respond to nothing, they either find an alternative solution or surgery quickly finds them. Combination-therapy helped me achieve it!
Moderator Ulcerative Colitis
, 40, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

My reviews on Yelp and Trip Adviser will be terrible: @$10,000 a night with uncomfortable beds and awful food, but at least the drugs are good at this hospital.

New Member

Date Joined Feb 2018
Total Posts : 14
   Posted 6/13/2018 3:58 PM (GMT -6)   
I stopped the antibiotic a while ago because I too thought it was odd that I was on it. Especially after having so many stool cultures done. The doctor believed that the specific antibiotic I was taking had an anti inflammatory component.

I can going to see another doctor on july 10th because I can't deal with my current one anymore. I am going to start entivyo in 2 weeks...I believe that if entivyo doesn't work my current doctor will then recommend surgery which I feel is not the route I need to be taking at the moment.

What is the difference between melsalmine and hydrocortisone enemas?

Forum Moderator

Date Joined Aug 2012
Total Posts : 12526
   Posted 6/13/2018 6:32 PM (GMT -6)   
Mesalamine is a topical, mild anti-inflammatory medication that treats inflammation from UC. Hydrocortisone is a topical steroid which suppresses the immune system which heals uc.

Veteran Member

Date Joined Aug 2008
Total Posts : 5963
   Posted 6/14/2018 8:21 AM (GMT -6)   
Hi there! My name is Chris and I usually post over on the ostomy forum, but I did post a lot here when I suffered with UP (my disease was mainly in the rectum). Just a few things. I think your GI doctor is right on target. Be grateful you have a GI doctor who even suggests surgery. All mine wanted to do was use me as a guinea pig for more and more meds during the twelve years I suffered with this dreaded disease. He refused to send me to a surgeon even when I was taking 17 to 25 pills daily, rectal meds, was prednisone dependent for two years straight and tried two biologics (Remicade and Humira) which both failed. My bowel movements were seven times per day, mostly just in the mornings and I had porta pots stationed in every room of the house and I live in a rancher because I couldn't make it to the bathroom. I missed out on weddings, funerals and my grandson's First Communion. Now, maybe your disease hasn't gotten this bad yet, only you can decide when you have had enough. However, when your quality of life is so deteriorated, you will know when enough is enough already.

The prednisone gave me extremely high blood pressure and diabetes. The 6MP gave me extremely high liver and pancreatic enzyme levels. I looked online to find a surgeon. I live in south Jersey but didn't want to have surgery here. So, I found a surgeon at Pennsylvania Hospital in Philly. Had my surgery in June of 2010 and never looked back. I only take one pill a day, and that is for my BP which is very well controlled, I no longer have diabetes and my quality of life is fantastic. I was not a candidate for j pouch, but I told my surgeon having a bag is a piece of cake compared to what I was going through with the disease. I am able to enjoy my two youngest grandsons, ages 3 yrs and the youngest just born this past March. Sorry I missed out on a lot with my oldest two, granddaughter is 21 and grandson 17. Who would think a 72 yr old could keep up with a 3 yr old, but I can!!!

Best of luck to you. Hope the meds do the trick, but I just wanted to let you know, surgery is NOT the end of the world. For me, it was the beginning. God bless.
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