Yes, certainly explore combinations of medications as they can produce results. Having an mesalamine-intolerance it does limit some choices for you. However, biologics (humira) and immunomodulators (MTX/6MP/Imuran) are often combined. And yes, you can try adding a potent probiotic like VSL#3.
Quick weans of prednisone seem like a waste of everyone's time (yours and theirs). Generally expect to be on pred for 2-months minimum as a bridge while you wait for a new medication or dosage change to work. Wait until you're 90%-100% healed on pred before you are taper off of it for best results. It takes a couple months to shutoff the immune attack and cease/reset that process. After which UC can be more tame.
What makes you think you have a misdiagnosis? If you have a copy of your colonoscopy report and biopsy reports then your diagnosis should be pretty rock-solid. It's easy to be in denial and wish it was something else.
Just make sure they check you for infectious causes, like c diff, which we are more prone to as UC patients. C diff mirrors UC flare symptoms, yet responds only to antibiotics and/or FMT (steroids and immuno-suppressants like Humira actaully make c diff worse). I'd get a minimum of two stool tests for c diff, as the test can produce false-negatives.
Yes, a surgery is permanent but provides a way forward without urgency and pain from UC flares. You can "hold it" again, you have predictability and certainly, and go about
your day without bathroom worries. All things an unending flare do not give us. Often people fail two biologics and try a number of things 1st, just to make sure there isn't another solution they haven't yet uncovered. Just good to know all of your options and that no matter what there is an out/escape if your UC proves to be uncontrollable through all medicinal means. You can have a good quality of life again, and that's encouraging.
Keep trying, maybe IntestinalWasps can recommend a good gasteroenteroligist team to get a second opinion and try some new thinking, and out of the box ideas. Often research-hospitals (like those found at major universities) are more current with the latest research and techniques, compared to older-school practices.
Post Edited (iPoop) : 4/19/2018 9:30:24 AM (GMT-6)