New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Hoda
Regular Member


Date Joined Jun 2017
Total Posts : 28
   Posted 7/11/2018 4:16 PM (GMT -6)   
Has anyone tried tacrolimus? Any feedback?

notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 16431
   Posted 7/11/2018 7:31 PM (GMT -6)   
Everyone who's tried it says it's been a miracle for quickly achieving remission. You do need monitoring though, and it's not usually seen as a long-term option, though I've seen some conflicting information overall. I didn't try it myself. It's mostly used as rescue and a bridge to another treatment. Is that what you're thinking? People also use it topically as suppositories - only somewhat recently i've seen this mentioned. Sounds like long-term oral use usually results in intolerable side effects over time, but this information is from a quick search on google, I am certainly not the authority.

My dog is on it daily for dermatitis and he does fantastic - it's been years. Interesting how a dog can use it daily without consequence.
Moderator: UC
Currently: no meds 6/15 Step 1 J-pouch Surgery Complete 9/15 Step 2 Complete 11/15 Step 3 Complete
From Sickly to UC Free

Give a man a fish and he will eat for a day; teach a man to fish and he will eat for a lifetime; give a man religion and he will die praying for a fish

Post Edited (notsosicklygirl) : 7/11/2018 6:35:30 PM (GMT-6)


ks1905
Veteran Member


Date Joined Sep 2005
Total Posts : 5114
   Posted 7/11/2018 7:53 PM (GMT -6)   
I haven’t but I’ve used a similar drug called Cyclosporine. It is very fast acting, my GI calls it the atomic bomb of UC weapons.

I liked it but does require an IV with hospitalization
Keith

DX'd with Severe Pancolitis June 2005
Previous Meds: 5ASAs, Predisone, 6-MP. Remicade, Humira, Simponi, Cimzia & Cyclosporine
3-step J-Pouch surgery: 2013 & 2014

Current Condition: Chronic Pouchitis -- Not as bad as I thought it would be
Current Meds: Stelara
Total Hip Replacement: 12/16 -- Thanks Prednisone!!!
www.healingwell.com/community/default.aspx?f=38&m=3755226

iPoop
Forum Moderator


Date Joined Aug 2012
Total Posts : 12761
   Posted 7/12/2018 7:29 AM (GMT -6)   
As other's have said IV tacrolimus is a short-term rescue medication much like IV-steroids, IV Cyclosporine, or double-dose IV Remicade are. Tacrolimus is a strong, fast-acting immunomodulator, much like Cyclosporine that works well for many while you're on it. Much like prednisone, Tacrolimus/Cyclosporine is only for temporary usage and therefore you need an escape plan for what you will use afterwards to sustain your quality of life (they buy you time while other maintenance treatment meds are given time to work). Tacrolimus/Cyclosporine is often used when someone is steroid-refractory (meaning IV steroids do not work). You'd take Tacrolimus/Cyclosporine with the hopes of that working or else you're slated for an emergency surgery for a colectomy. It's one of those nuclear weapons we have in our arsenal but only used sparingly when everything is FUBAR (F'ed/Fouled Up Beyond All Recognition/Any Repair/All Reason) and there is no other choice but to try it to tame a flare.

Some teaching-hospitals might try to use Tacrolimus/Cyclosporine in more novel ways, and perhaps not as a last-ditch effort as would be done in more traditional GI-practices. For example, I've heard of Tacrolimus Suppositories being used experimentally in some UC patients, sometimes with results.

Embellish us a little bit about your situation, whats' the current state of your UC?, what meds are you currently on?, and How bad are your UC symptoms?
Moderator Ulcerative Colitis
John
, 40, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

With UC, we're much like a footballer on our way to the bathroom: running, jumping over and agilely dodging around obstacles, and knocking out-of-the-way all that are in our path to the end-zone.

Post Edited (iPoop) : 7/12/2018 6:36:02 AM (GMT-6)


ks1905
Veteran Member


Date Joined Sep 2005
Total Posts : 5114
   Posted 7/12/2018 1:53 PM (GMT -6)   
My GI will use Cyclosporine for upto 12 months. I've taken it for 6-7 months while the 6-mp was kicking in.
Keith

DX'd with Severe Pancolitis June 2005
Previous Meds: 5ASAs, Predisone, 6-MP. Remicade, Humira, Simponi, Cimzia & Cyclosporine
3-step J-Pouch surgery: 2013 & 2014

Current Condition: Chronic Pouchitis -- Not as bad as I thought it would be
Current Meds: Stelara
Total Hip Replacement: 12/16 -- Thanks Prednisone!!!
www.healingwell.com/community/default.aspx?f=38&m=3755226
New Topic Post Reply Printable Version
Forum Information
Currently it is Thursday, July 19, 2018 3:16 AM (GMT -6)
There are a total of 2,983,059 posts in 327,076 threads.
View Active Threads


Who's Online
This forum has 161882 registered members. Please welcome our newest member, MMor10.
228 Guest(s), 2 Registered Member(s) are currently online.  Details
JohnMorales, Bloodyhell