I haven't touched on the safety concerns with the long term antibiotic combination either. I think this should be adressed very carefully. It is now known through scientific studies and many articles that bactericidal antibiotics induce mitochondrial dysfunction, which should be expected based on the endosymbiotic theory. They have toxic effects on your mitochondria, one of the known mechanisms for that is oxidative stress. I can't remember right now about
clofazimine and rifabutin; but there are many in vivo and in vitro studies demonstrating that macrolides (clarithromycin) have bacteriostatic and bactericidal effects.
Ask another question: How do these antibiotics combination affect brain physiology in the long term (since this is meant to be a long term antibiotic treatment)? Do they cause any permanent changes in your brain? It is known through scientific studies that clarithromycin has excellent CSF penetration.
Macrolides are one of the most potent antibiotics for causing antibiotic induced serious psychiatric problems, for example.
How do these antibiotics affect your cognitive function? How do they affect you neuroendocrinologically?
I have asked these to Dr. Chamberlin, and he said he doesn't have knowledge about
these, but he thinks
the long term antibiotics treatment is safer than the standart Crohn's treatments.
This one year old study will not do it for me in terms of safety concerns. They don't look at these and many other possible physiological changes in the treatment subjects. They probably did very standart blood tests and if something very suspicious occurs, then looked for that isolated problem. I don't expect a drug company to do a thorough examination of a drug's effects on the trial subjects based on its molecular structure, and the literature about
its possible mechanisms of action, its effects on various organisms, hypothetical questions and safety concerns raised about
Compare this with Humira, for example. Humira has no direct toxic effect on human cells and tissues. Anti-tnf's have been used for a long time to collect a good amount of pharmacovigilance data. The only problems that occur with the anti-tnf's are actually secondary effects of the tnf inhibition (slightly increased risk of cancer and fatal infections).
Post Edited (xy123) : 8/4/2018 1:29:31 AM (GMT-6)