If nothing else, there's always Uceris-oral, or steroid enemas or steroid foams to get us by when struggling. I hear you, the not-knowing is what kills us. Ultimately we make our best, educated guesses that are supported by test results (when possible), cross our fingers and hope for the best. Unfortunately, nothing is infallible or fool-proof, and we might need a "plan B." There's always a bit of trial-and-error in it all.
Options discussed thus far:
1.) Imuran will take 3-months to make noticeable differences, if you started it today.
2.) An increase in Humira dosage might take a series of weeks to take affect (2-5 weeks).
3.) Steroids will kick in within a week's time or less. If you choose the 90%-topical varieties then the odds are it will not make you totally crazy. For oral administration that would be Uceris/Entocort EC/Clipper/Budesonide. For Rectal-route that'd be Steroid (Budesonide/Hydrocortisone) enemas, suppositories, or foams (Uceris foam, Colifoam). A temporary bandaid while you try the other above mentioned things, cross your fingers, taper off and hope the new solution is sufficient.
4.) Switch biologics a process that can take a series of months to produce measurable results. They'd likely put you on prednisone while stopping humira and going through the new biologic's loading dosages.
I'd lay your options infront of you, give it some thought, talk them over with your gasteroenteroligist and see what you both decide is the best course of action for your current symptoms.
Post Edited (iPoop) : 9/10/2018 1:06:15 PM (GMT-6)