I'd ask his gasteroenterologist about
getting an infliximab/remicade blood test done to check his level of that medication and whether there are any antibodies present. https://www.labcorp.com/test-menu/29496/infliximab-concentration-and-anti-infliximab-antibody
20% begin loosing response to remicade and increasing the dosage (from 5mgs per kilogram of body weight to 10mgs) and/or frequency of remicade infusions (from 8 weeks to 6 or 4 weeks) often brings patients back into a response.
Other biologics work when failing one, in most cases.
Moderator Ulcerative Colitis
John, 40, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasaDid you realize that if you sit on the toilet at 11:59 and then clock strikes midnight, it's the same crap, different day?