But wasn't that debunked years ago when large scale data started coming in that showed similar rates of antibody formation for Remicade and Humira?
Not to my knowledge but I could be entirely wrong. If you can find the study and data then post it and I'll be glad to give it a read. The whole antibody thing seems to be a bit of a gray-area, where we kinda think we know what is going on but aren't always right. Some get antibodies while following the best practices. Some do not follow any best practices yet do not get antibodies.
Yesterday evening, I spent a lot more time than I should've crawling scholar.google to see if I could back my claim but unfortunately could not lol. I read one thing that said it was as effective at preventing antibodies to start a biologic while on pred, as to start a biologic while on immunomodulators, which I found interesting. Certainly, it seems, initial exposure to a biologic is a high period of risk for antibody formation. Having waning levels of a biologic (too low of a dose) seems to trigger antibody formation too. Mirrors viral infections for us though, that initial exposure to a virus is when our immune system aggressively tries to stop an invader, and when the virus is nearly defeated through other means (body temp rise, etc etc) our immune system aggressively tries to find antibodies in case we encounter that virus again or a similar variant thereof. And, of course, a biologic looks no different to our bodies than a virus does (like influenza or the common cold).
Post Edited (iPoop) : 1/17/2019 6:27:14 AM (GMT-7)