I am not sure where they are going with it, but they are finding methods of determining risk scores of who is the most likely to later develop Crohn's. Key is you have a first-degree-relative with Crohn's. They assessed folks, followed up later and some did develop Cohn's (when they did not initially have it when the study started). Some of the data initially collected is determined to have been somewhat predictive of higher risk.
"Additionally, the GEM Project confirmed that genetic risk score did correlate with disease development with those in the highest risk quartile 2.6 times more likely to develop Crohn’s than the other quartiles
(HR = 2.6; 95% CI, 1.25-5.41)."
"One factor of IBD that the GEM study includes is gut permeability, Croitoru said. He showed permeability data from the first 1,300 patients in which they collected the data and showed that those with abnormal permeability were three times as likely to develop disease
(HR = 3.2; 95% CI, 1.73-5.93)."
"Additionally, Croitoru presented preliminary data on gut diversity and disease risk. He showed that those patients with the lowest diversity were 50% more likely to develop Crohn’s disease than those in the quartile with the most diversity
(HR = 0.47; 95% CI, .93-1)."
Moderator Ulcerative Colitis
John, 40, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasaEven Superman couldn't hold back the insurmountable force of UC urgency. But I bet those spiffy spandex shorts would at least hold in the mess!
Post Edited (iPoop) : 2/12/2019 9:01:25 AM (GMT-7)