No surprise that an oral mesalamine like Apriso or Lialda can gradually dissipate, all meds do, but that is why many here can maintain longer remission by reinforcing oral mesalamines with rectal enemas, (not suppositories). Not only are enemas very effective but they also have the fewest side effects. Take them regularly at first but hopefully soon they will be necessary only when needed.
I would make sure that your doctor answers all your questions. For example none of the biologic drugs are available as a generic version, so they are all very expensive, ranging from $2,000 to more than $5,000 per month in maintenance.
Of course biologics have much stronger side effects, e.g. from now on you may be forced to be much more careful avoiding sunlight at the beach. And it is best practices that once on biologics you will probably remain on them at least for a very long time. But as poopydoop says, sometimes you have no choice.
Male, born 1951, DX IBD Feb08. No meds, allergic to Mesalamine.
Food diary instead of SCD or Paleo.
When needed probiotics taken with powdered psyllium seed is very helpful.
Probiotics, Lactobacillus Reuteri (NCIMB 30242), Fish oil, curcumin, black cumin, lobelia, extra D3, magnesium, multivitamin, glutamine when gut repair needed.
Resistant Starch and lots of fruit & vegetables (but no cruciferous), No Gluten, no soda, no HFCS, no shellfish. No processed foods with carrageenan, maltodextrin, sorbitol, carboxymethylcellulose, or polysorbate80. No GMO foods saturated with Roundup.Nature created all of the locks, therefore Nature has all of the keys
Post Edited (IamCurious) : 3/14/2019 6:28:20 PM (GMT-6)