I will say it again
People on biologics must constantly be on guard for infections.
Remicade weakens your immune system's response to infections. Another dose of remi might further strengthen an infection, make it harder to treat, and cause the infection to spread. If you have an active infection requiring antibiotics and you need remicade today or soon then call and they will likely delay your infusion until your course of antibiotics is complete and that infection is gone.
is 6MP's potential to cause serious infections related to the degree of suppression to the WCC (white cell count)? Yes, 6mp/Aza/Imuran works by lowering your white blood cell count. A little background, your immune system uses white blood cells (more specifically T-cells, one of three types of Lymphocytes) to attack infected tissue within the body, which causes inflammation, and kills infected/diseased cells. 6mp lowers your white blood cel count so less inflammation is caused in your large intestine but the effect of 6mp is systematic (meaning it effects your whole body and not just the intestine). While on 6mp, you will undergo regular blood tests. A CBC blood test counts the white blood cells present among other things and makes sure it doesn't get below a certain level.
So if i get my bloods checked every month and make sure my WCC does not drop too low am i still at risk of these infections? Yes, even with monitoring your white blood cells are still decreased and therefore your body is less able to fight infections when they occur. That can mean an infection, cold, or flu lasts longer than normal. It can mean that you need to seek medicinal treatment sooner in the case of a UTI, bronchitis, or other such infection. Otherwise, those infections may spread or get worse much quicker than you'd otherwise expect.
The key thing is being more alert, cautious, and to seek treatment when early signs emerge of an infection. This is important as your immune system is suppressed and therefore less capable of fighting the infection on its own.
Yes, immunosuppressive medications (Imuran, 6mp, aza) and biologics (remicade, humira, simponi) increase your odds of getting infections such as UTIs, bronchitis, sinus, etc. That's because those medications lower your body's capability to fight infections and cause inflammation.
Remicade increases ones odds of getting infections, e.g., bronchitis, sinus, urinary tract infections, etc. This is because remi is systematic, and reduces the whole body's natural process of causing inflammation to target and clear out infected cells. Due to a weakened immune system, they can quickly become serious infections. You're best to be vigilant and see your doctor upon first signs of those sorts of infections. Take a course of medication early to treat them.