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Question about prednisone and UC

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Ulcerative Colitis
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M00NMAN18
New Member
Joined : Sep 2016
Posts : 9
Posted 8/22/2019 1:12 PM (GMT -6)
Hello,
I'm about to start a course of prednisone (35mg)
Is it advisable to get screened for latent tuberculosis before starting prednisone? I know it's a requirement for Remicade and such but what about corticosteroids?
Thanks.
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iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16208
Posted 8/22/2019 1:38 PM (GMT -6)
No screenings needed before starting Prednisone. That is only recommended for Remicade (and other TNF-alpha blocking bioligics like humira and simponi), as it popped up during the clinical trials, a few patients had latent TB pop up again, there was a recommendation put on the packaging to screen for TB in advance, and it is standard practice for our doctors. Thiopurines do not require screenings either (6-mercaptopurine, Imuran/azathiopurine).

Hypothetically, could prednisone or 6MP cause latent TB to popup again, sure. Either the clinical trials were done too long ago (both were initially approved decades ago), and/or there hasn't been enough of a problem to warrant adding it to the packaging.

The packaging for remicade only mentions TB. Some doctors also screen for Hep C which is another latent infection. Others could do this too.
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Sara14
Veteran Member
Joined : Mar 2007
Posts : 6235
Posted 8/26/2019 5:05 PM (GMT -6)
No.

And 35 mg is kind of a low dose to start for a UC flare. All the GIs I've ever had started me at 40 (and now I have to start at 50). Anyway, good luck!
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