Thanks for sharing. You were right about
it saying 40%. But you're also right that newer medications may reduce that risk.
Another thing that may reduce risk compared to this: This data was accumulated on people before colonoscopies were routinely done. Screening colonoscopies have led to doctors finding pre-cancerous lesions and/or polyps and removing them before they become cancerous.
What's more, their numbers are the highest I've seen. You seem to have found the study with *the* worst outlook/data there is!
It's from a single population cohort (a single group of people) in a single country.
f you look at other, similar studies done more recently, the numbers are lower, even for highest risk patients (like those diagnosed young with pancolitis).
There are dozens of studies looking at rates of colorectal cancer for people with UC, and the results are all over the place in terms of just high much the rates are increased compared to the 'normal' population.
Look at some newer data and you'll see that none of it shows rates as high as the study you linked to.