Open main menu ☰
HealingWell
Search Close Search
Health Conditions
Allergies Alzheimer's Disease Anxiety & Panic Disorders Arthritis Breast Cancer Chronic Illness Crohn's Disease Depression Diabetes
Fibromyalgia GERD & Acid Reflux Irritable Bowel Syndrome Lupus Lyme Disease Migraine Headache Multiple Sclerosis Prostate Cancer Ulcerative Colitis

View Conditions A to Z »
Support Forums
Anxiety & Panic Disorders Bipolar Disorder Breast Cancer Chronic Pain Crohn's Disease Depression Diabetes Fibromyalgia GERD & Acid Reflux
Hepatitis Irritable Bowel Syndrome Lupus Lyme Disease Multiple Sclerosis Ostomies Prostate Cancer Rheumatoid Arthritis Ulcerative Colitis

View Forums A to Z »
Log In
Join Us
Close main menu ×
  • Home
  • Health Conditions
    • All Conditions
    • Allergies
    • Alzheimer's Disease
    • Anxiety & Panic Disorders
    • Arthritis
    • Breast Cancer
    • Chronic Illness
    • Crohn's Disease
    • Depression
    • Diabetes
    • Fibromyalgia
    • GERD & Acid Reflux
    • Irritable Bowel Syndrome
    • Lupus
    • Lyme Disease
    • Migraine Headache
    • Multiple Sclerosis
    • Prostate Cancer
    • Ulcerative Colitis
  • Support Forums
    • All Forums
    • Anxiety & Panic Disorders
    • Bipolar Disorder
    • Breast Cancer
    • Chronic Pain
    • Crohn's Disease
    • Depression
    • Diabetes
    • Fibromyalgia
    • GERD & Acid Reflux
    • Hepatitis
    • Irritable Bowel Syndrome
    • Lupus
    • Lyme Disease
    • Multiple Sclerosis
    • Ostomies
    • Prostate Cancer
    • Rheumatoid Arthritis
    • Ulcerative Colitis
  • Log In
  • Join Us
Join Us
☰
Forum Home| Forum Rules| Moderators| Active Topics| Help| Log In

Article, dysbiosis, FMT, and colonization of bacterium

Support Forums
>
Ulcerative Colitis
✚ New Topic ✚ Reply
❬ ❬ Previous Thread |Next Thread ❭ ❭
profile picture
iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16189
Posted 10/21/2019 1:51 PM (GMT -7)
An interesting read, haven't heard FMT mentioned much lately. This goes through the colonization of bacterium from FMT, who is colonized and in what abundance and talks about dysbiosis. Interesting read for those interested in this nerdy kinda stuff.

"Fecal microbiota transplantation (FMT) aims to modify the intestinal microbiota composition and function of the recipients by transferring donor fecal suspension into the gastrointestinal tract of a recipient, and has become a promising method for manipulating the gut microbiota. Its successful application for the treatment of Clostridium difficile infection has inspired people to apply it to inflammatory bowel disease patients (8,9,10,11,12,13). However, this application is still in its early stages. According to a recent systematic review and meta-analysis, after minimizing publication bias, IBD patients who received FMT had a remission rate of only 36.2%: 22% for UC and 60.5% for CD (14)."
"We found that 3 days after FMT, 11 out of 15 recipients were in remission (3 out of 4 UC recipients; 8 out of 11 CD recipients). Generally, bacterial colonization was observed to be lower in CD recipients than in UC recipients at both species and strain levels. Furthermore, across species, different strains displayed disease-specific displacement advantages under two-disease status. Finally, most post-FMT species (> 80%) could be properly predicted (AUC > 85%) using a random forest classification model, with the gut microbiota composition and clinical parameters of pre-FMT recipients acting as factors that contribute to prediction accuracy"


https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12744
profile picture
DBwithUC
Veteran Member
Joined : Feb 2011
Posts : 4545
Posted 10/22/2019 6:34 AM (GMT -7)
This is good work. The specific processes and the extent of colonization needs to be understood if it is ever going to be figured out whether dysbiosis contributes to UC, or UC produces dysbiosis.

Because it is such a short term span of time examine (4 points in one month) I think they should not use words like remission, which is a sustained absence of inflammation. If fact they never looked to see if inflammation was truly gone. Maybe they should have said at 3 days there was an abeyance of symptoms. 75% of UC patients in trials and studies do not get remission, so that is a glaring discrepancy that is likely due to their confusing vocabulary.

The more interesting part to me was the somewhat cryptic remarks about prediction of colonization patterns. The two most powerful predictors were the distributions of gut microbe populations before FMT, and the clinical features (e.g., type of IBD, inflammation, location, motility, GI symptoms) of the patient pre-FMT. This suggests that it may be possible to identify groups of patients more likely to obtain colonization, or determine when in IBD course FMT has a better chance of altering gut microbes.
✚ New Topic ✚ Reply

More On Ulcerative Colitis

7 Ways To Support Someone With Crohn's Or Colitis

7 Ways To Support Someone With Crohn's Or Colitis

8 Foods To Avoid With Ulcerative Colitis

8 Foods To Avoid With Ulcerative Colitis



HealingWell

About Us  |   Advertise  |   Subscribe  |   Privacy & Disclaimer
Connect With Us
FacebookFacebook TwitterTwitter InstagramInstagram PinterestPinterest LinkedInLinkedIn
© 1997-2021 HealingWell.com LLC All Rights Reserved. Our website is for informational purposes only. HealingWell.com LLC does not provide medical advice, diagnosis, or treatment.