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Study: Entyvio compared to Humira

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Ulcerative Colitis
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Sara14
Veteran Member
Joined : Mar 2007
Posts : 6235
Posted 10/30/2019 7:51 AM (GMT -7)
"The patients were randomly divided into two groups with different drugs (adalimumab and vedolizumab ) administered to each group. There were several criteria for the research: clinical efficacy, the manifestation of the symptoms of the disease (participants filled in electronic diaries indicating the frequency of defecation, bleeding, abdominal pain, etc.), the results of colonoscopy before and after therapy, the results of histological examination, etc. The research has shown that vedolizumab is 9-12% more effective."

https://medicalxpress.com/news/2019-10-scientists-counter-ulcerative-colitis.html
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Sara14
Veteran Member
Joined : Mar 2007
Posts : 6235
Posted 10/30/2019 8:02 AM (GMT -7)
So, I skimmed through the actual study after reading that article and it actually sounds like Humira had a higher remission rate, so that article I posted above was super poorly written. They talk about clinical remission (where Entyvio did better) and then they give other percentages for "corticosteroid-free remission" (where Humira did better). I thought it wasn't remission if you were still on steroids???

"A total of 769 patients underwent randomization and received at least one dose of vedolizumab (383 patients) or adalimumab (386 patients). At week 52, clinical remission was observed in a higher percentage of patients in the vedolizumab group than in the adalimumab group (31.3% vs. 22.5%; difference, 8.8 percentage points; 95% confidence interval [CI], 2.5 to 15.0; P=0.006), as was endoscopic improvement (39.7% vs. 27.7%; difference, 11.9 percentage points; 95% CI, 5.3 to 18.5; P<0.001). Corticosteroid-free clinical remission occurred in 12.6% of the patients in the vedolizumab group and in 21.8% in the adalimumab group (difference, −9.3 percentage points; 95% CI, −18.9 to 0.4)."

https://www.nejm.org/doi/10.1056/NEJMoa1905725
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Sara14
Veteran Member
Joined : Mar 2007
Posts : 6235
Posted 10/30/2019 8:04 AM (GMT -7)
Ok, that study was funded by the maker of Entyvio and it sounds like the results could have been skewed to favor it. Sorry for posting this before I read the actual study.
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