Posted 10/30/2019 8:02 AM (GMT -7)
So, I skimmed through the actual study after reading that article and it actually sounds like Humira had a higher remission rate, so that article I posted above was super poorly written. They talk about clinical remission (where Entyvio did better) and then they give other percentages for "corticosteroid-free remission" (where Humira did better). I thought it wasn't remission if you were still on steroids???
"A total of 769 patients underwent randomization and received at least one dose of vedolizumab (383 patients) or adalimumab (386 patients). At week 52, clinical remission was observed in a higher percentage of patients in the vedolizumab group than in the adalimumab group (31.3% vs. 22.5%; difference, 8.8 percentage points; 95% confidence interval [CI], 2.5 to 15.0; P=0.006), as was endoscopic improvement (39.7% vs. 27.7%; difference, 11.9 percentage points; 95% CI, 5.3 to 18.5; P<0.001). Corticosteroid-free clinical remission occurred in 12.6% of the patients in the vedolizumab group and in 21.8% in the adalimumab group (difference, −9.3 percentage points; 95% CI, −18.9 to 0.4)."
https://www.nejm.org/doi/10.1056/NEJMoa1905725