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Can taking PPI long have adverse affects

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GodLevel
Regular Member
Joined : Jun 2019
Posts : 46
Posted 11/23/2019 11:20 AM (GMT -7)
Hi guys, can PPI if taken for longer have adverse affects. I ahve been taking it for many months. I dont take it everyday but take half a month PPI ( cyra it- Rabeprazole 20/Itopride 150mg) and and half a month Used to pantocid 40.
I dont feel any side effects , but can anyone tell will it have any adverse affects on my health in the long run which I could not notice?
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quincy
Elite Member
Joined : May 2003
Posts : 32548
Posted 11/23/2019 11:30 AM (GMT -7)
There can be side effects, I haven't had any except less stomach pain which is a plus.

q
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GodLevel
Regular Member
Joined : Jun 2019
Posts : 46
Posted 11/23/2019 12:16 PM (GMT -7)
I feel great after taking PPI antacid, no heatburn , less acidity , less pain. But at the same time , after searching on google , I am worried because they say that PPI can result to heart disease , increased production of gastric acid after PPI will be stopped which may lead to stomach ulcers too or even gastric cancer. Can anyone help me , that should I continue PPI use? Or stop them immediately?
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straydog
Forum Moderator
Joined : Feb 2003
Posts : 18304
Posted 11/23/2019 1:59 PM (GMT -7)
First, I suggest that you stay off of Google. Any medication including some OTC can have potential side effects. Does it mean it will happen to you, no. If I read your post right you are using the PPI's on a part time basis. How long have you been on them?

I have not ever heard of them causing causing cancer or heart issues. I have some heart problems & have been prescribed them. I would think if I shouldn't have them, one of my drs including my cardiologist would have said something.

You should avoid caffeine, alcohol & spicy foods. Elevate the head of your bed at least 6 inches, avoid eating right before going to bed.

You appear to be quite anxious, you should discuss your fears with your dr. Also, your pharmacist is a good source that can answer your questions about any medication.
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IamCurious
Veteran Member
Joined : Jan 2010
Posts : 3550
Posted 11/23/2019 2:22 PM (GMT -7)
I agree with Straydog, please consult with your doctor if long term gastroesophageal reflux disease (GERD) can lead to precancerous conditions. And ask him/her if the usual treatment, typically proton pump inhibitors (PPIs), can reduce stomach acids causing low absorption of nutrients (e.g. B12), intestinal dysbiosis, and small intestinal bacterial overgrowth (SIBO).

AstraZeneca, the maker of both Prilosec® and Nexium®, recommends their use only for short periods of time in its package inserts.

Several studies have looked at the impact of using probiotic supplements along with PPIs. In a randomized clinical trial, children with GERD were treated with a PPI plus either a probiotic containing 100 million CFUs of L. reuteri DSM 17938 per day or a placebo. After 12 weeks, SIBO was detected in 6.2% of those who received the probiotic and 56.2% of those who received the placebo. A similar trial in adults with GERD found that a probiotic containing L. paracasei F19 prevented treatment-related bloating, flatulence, and abdominal pain.

Taking calcium and magnesium carbonates to reduce acid might help. The main ingredient in TUMS, which is OTC, is calcium carbonate.

You can always try d-limonene, an extract from orange peels. This is purely anecdotal and yet unpublished clinical research, but it appears to help some people. D-limonene shouldn't have too many side effects but it is not recommended for pregnant or nursing women, or people who have or suspect that they have ulcers.

Life Extension sells Raft-forming alginate:
https://www.lifeextension.com/vitamins-supplements/item01737/esophageal-guardian
”creates a physical barrier “raft” to block reflux from occurring, protecting esophageal tissue from corrosive stomach contents. Alginate is clinically proven to reduce the frequency and intensity of reflux attacks, with effects equivalent to antacid medications that have substantial side effects.”
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MarkWithIBD
Regular Member
Joined : Jun 2018
Posts : 442
Posted 11/23/2019 11:10 PM (GMT -7)
The two main risks with them are mineral and B12 malabsorption, since they affect production of intrinsic factor is suppressed by PPIs.

The second risk is lower GI infection because stomach acid destroys a lot of pathogens before they can go deeper into the body.

The first risk I mentioned is more common than the second.
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ambling
Veteran Member
Joined : Feb 2011
Posts : 1034
Posted 11/23/2019 11:38 PM (GMT -7)
Raft-forming alginate is just good old gaviscon!

Lifeextension is a horrible product ( and a dodgy magazine) with xylitol, mannitol and of course cornstarch and maltodextrin...
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quincy
Elite Member
Joined : May 2003
Posts : 32548
Posted 11/24/2019 11:52 AM (GMT -7)
High dosage of aluminum isn't good either....especially considering it's the main active ingredient in Gaviscon.

q
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ambling
Veteran Member
Joined : Feb 2011
Posts : 1034
Posted 11/24/2019 3:37 PM (GMT -7)
Quincy, aluminium hydroxide isn't aluminium (it isn't bioavailable ) but there are other formulations of chewable gaviscon . contains Sodium alginate 250mg, Sodium bicarbonate 133.5mg, Calcium carbonate 80mg.
I'm not recommending!

They tend to use xylitol and mannitol to counteract the slowing of smooth muscle contractions, caused by alginate ...but that can cause diarrhoea in some.

OP, getting back to your question, yes interrupting acid production in the stomach isn't ideal. If you need it long term, try smaller doses perhaps. And take breaks if possible. Eating foods that require lower acid levels can help some. It is a tricky problem.

Post Edited (ambling) : 11/24/2019 3:42:02 PM (GMT-7)

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CCinPA
Veteran Member
Joined : Dec 2014
Posts : 1572
Posted 11/24/2019 3:37 PM (GMT -7)
I read those scary stories on google too. I had been on omprazole for almost 2 years for silent acid reflux (only symptom was a horrible cough that would not go away until I took the ppi). I got really worried about long term use and slowly weaned myself off of them. The cough returned with a vengeance and omeprozole wouldn't work any more. I'm now on dexilant and take it every other day. That seems to be working just fine. I may try to stretch it longer at some point.

For me I decided the risks of long term acid reflux were more dangerous that the ppis. Maybe one day I can get off of them, but for now it's a quality of life issue for me
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