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Entyvio - how long to see improvement?

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Ulcerative Colitis
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Posted 12/2/2019 12:14 PM (GMT -6)
Hi all, just curious, if you use/have used Entyvio, how long did it take for it to work? Did you use Imuran or something similar alongside it? After what period of time would you consider it a failure?

I have browsed some old conversations about this and see that it takes a while for Entyvio to work, but I haven't come across any specific durations.

I've been on for two and a half months and might be a little better...still bleeding and can't get off of the steriods.

Thanks!
Posted 12/2/2019 12:28 PM (GMT -6)
I think my doctor told me it can take 6-8 months to completely work, but I may be remembering that incorrectly. I haven't tried it yet. Have you asked your doctor how long you should wait before considering it a failure? It seems like a very long time to wait. What dose of pred are you stuck on, just curious?
Posted 12/2/2019 3:36 PM (GMT -6)
My doctor said we would start to think it a failure at around 6 months. I was just curious if this was the norm and it seems to be. They are suggesting that I consider adding imuran now though.

I start bleeding if I go below 10mg prednisone but it used to be 20 mg so I guess that’s good! Still have lots of symptoms at each dose, though, just not the blood so much.

Thank you for responding
Posted 12/2/2019 4:41 PM (GMT -6)
I started tapering off Predisone with my first infusion. I don’t recall how long that taper took but it was as most likely a month. I’d say I was In symptomatic remission at 4 months although a colonoscopy around that same time showed no visible inflammation but some at the microscopic level. After I was off prednisone I used Canasa and Uceris foam. I had bloodwork done that showed I was a nonmetabolizer of the 6mp class of drugs so I never tried those but I did take methotrexate for a few months in the beginning.
Posted 12/2/2019 7:23 PM (GMT -6)
My doctor told me 10 weeks I would know if I am having a response. I have seen a lot of people wait longer and have success though.
Posted 12/3/2019 7:19 AM (GMT -6)
My doc pulled the plug at 14 weeks. Actually i insisted on having the 4th infusion because it did more than nothing (i was able to taper off pred, needed to do that because of severe osteoporosis) but I had so much pain my life was intolerable...i switched to xeljanz which took about 5 weeks to really kick in (then 4 months to full remission)
Posted 12/3/2019 7:34 AM (GMT -6)
My fecal cal protectin went from 200 to 30 by week 8 after starting Entyvio
Posted 12/4/2019 11:51 AM (GMT -6)
Thank you all for sharing your experiences! I think I'll continue to work with it for another month or two before adding Imuran.
Posted 12/4/2019 1:25 PM (GMT -6)
I hope it gets you into remission soon!
Posted 12/7/2019 4:29 PM (GMT -6)
My doctor told me some people can see improvement at 2 to 3 weeks but 14 weeks was the normal. They can also adjust the dosage or frequency.
Posted 12/7/2019 4:36 PM (GMT -6)
it took about three months for me. Sloooowww but sure, hopefully!
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