This is no secret that those with UC usually has significantly increased numbers of proteobacteria in their guts. Normally proteobacteria accounts for only about
1-2% of gut microbiota but I have seen tests of UC patients with proteobacteria reaching 15-18% of gut microbiota. Usually the higher the percentage of proteobacteria the more severe UC state the patient has. Any animal protein (not only meat) is what generally this phylum of bacteria feed on. They thrive in environments that are rich with sulphur containing compounds, amino-acids isoleucine, leucine, valine and fatty acids. This is why anyone with UC should check MTHFR deficiency as it results in a build-up of homocysteine, and if sulfonation pathway cannot buffer homocysteine buildup you end up with increased sulfite/sulfide production. Proteobacteria does their damage by generating hydrogen sulfide (H2S) from sulhur compounds in the bowel. Hydrogen sulfide (well known for its rotten egg smell) is extremely toxic and does heavy damage to epithelial barrier very rapidly. Once the gut wall is damaged the immune system comes in contact with LPS (lipopolysaccharide) that is part of the outer membrane of proteobacteria. This immediately elicits strong immune response and inflammatory cascade resulting in typical severe UC symptoms like diarrhea, bleeding etc.
The good news is that plant based diet can indeed help as it promotes production of SCFAs, primarily butyrate, acetate, and propionate, from undigestible carbs like fiber and resistant starches. But before going high fiber one thing to take into account is that you cannot go plant based and high fiber cold turkey while your gut is still inflamed. If your bowel is inflamed going high fiber will most probably be catastrophic to you as SCFAs cannot be uptaken in inflamed epithelia anyway and you will most probably experience more severe symptoms due to "hard" nature of fiber. So first and foremost thing you need to do is to get inflammation down and under control with diet (low fat, no animal protein, low residue) and any pharmaceuticals, anti-inflammatories, steroids or immunosuppressives that work for you. I would also suggest using anti-inflammatory enemas (e-vitamin in combo with mesalazine). Once you have gotten inflammation under control you can gradually start introducing more fiber to change your gut composition to that which generate SCFAs. Once you are in stable remission you can try to get back to meat if you like. So basically protocol is like this – 1) low residue, low fat, no animal protein, no dairy diet; 2) medicals, antibiotics like Metronidazole, anti-inflammatories to get inflammation under control; 3) when no bleeding and stable gut gradually start introducing fiber; 4) when in remission for longer start getting back to noraml diet. During all this time you must control stress levels
P.S. Animal protein = meat, eggs, fish and dairy (milk, cheeses, creams etc)
Post Edited (Globetrotter) : 12/4/2019 12:54:08 PM (GMT-7)