"They found that one strain of L. paracasei actually extended the lifespans of the worms they gave it to, and this observation applied even to the bacteria that the researchers had inactivated with heat.
Going forward, the team decided to test the inactivated L. paracasei strain in elderly mouse models, meaning to emulate the health condition of older humans who are naturally more exposed to metabolic dysregulations and, as recent research has suggested, to leaky gut syndrome.
Our intestinal walls feature a mucosal barrier — a layer of mucus that prevents gut bacteria from leaking into the blood, and other elements that the blood carries from leaking into the gut. This natural barrier should prevent infections and contribute to the maintenance of our general health.
However, as we grow older, this barrier becomes increasingly permeable, allowing leakages to occur more easily, and eventually leading to the occurrence of generalized, low level inflammation. This is, in itself, a risk factor for other conditions, including diabetes, obesity, as well as cardiovascular and cognitive problems.
"We know that probiotics are instrumental in maintaining a healthy gut and preventing leakage, but there isn't much data available to pinpoint which ones work and which ones don't," notes lead researcher Hariom Yadav, Ph.D.
"Determining the strain that is most effective at reducing leaky gut and inflammation would help us target more effective strategies to address the problem, and help explain why probiotics work for some people but not others," he continues."https://www.medicalnewstoday.com/articles/amp/327276