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Lialda shortage

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Ulcerative Colitis
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seanyd
Regular Member
Joined : Oct 2015
Posts : 27
Posted 2/4/2020 5:12 PM (GMT -7)
Anyone else here having an issue filling their Lialda prescriptions? I've been trying since last week and it is still on backorder at my local CVS. Walgreens and Costco both have nothing as well. I leave for vacation tomorrow and I run out Sunday. Not ideal.
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greenuc
Regular Member
Joined : Sep 2011
Posts : 266
Posted 2/5/2020 3:18 AM (GMT -7)
Yes, had to switch to generic.
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UCinGV
Regular Member
Joined : Mar 2007
Posts : 499
Posted 2/5/2020 6:42 AM (GMT -7)
Get the generic. I've tried many generics and in my limited experience each one of them is actually more effective than the brand.
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greenuc
Regular Member
Joined : Sep 2011
Posts : 266
Posted 2/5/2020 5:11 PM (GMT -7)
I had some leftover Lialda so I first moved to 2 Lialda per day and 2 generic per day. So far, no negative impact from that move and I'm 10+ days in.
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Dazataz
New Member
Joined : Feb 2020
Posts : 13
Posted 2/11/2020 9:41 AM (GMT -7)
This is urgent issue for many of us. I found Zydus' generic made my initial Dx of UC much worse. Total fail and I was on canasa & cortifiam and uceris. Went from mild/mid to mod/severe in 6 months.
Switched to Lialda, started immediate gradual improvement.
I ran out Jan 8, usually mail order for 3 months. fought for weeks to refill, manager @ optumrx and I called every store within 50 miles in NJ. I found 1 bottle. Took it and got the other 2, last week.
The generic has a different coating & doesn't dissolve in the colon correctly.

Post Edited (Dazataz) : 2/11/2020 12:35:13 PM (GMT-7)

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UCinGV
Regular Member
Joined : Mar 2007
Posts : 499
Posted 2/11/2020 11:27 AM (GMT -7)

Dazataz said...

The generic has a different costing & doesn't dissolve in the colon correctly.

I know different "generic Lialda" from different manufacturers has different coatings. Some of them are clearly dissolubule in saliva (Zydus's version) and others are not(Sun Pharma, Actavis). I haven't tried the generic from Mylan.

I assume the generics with the coating that does not dissolve in saliva use the same coating as brandname Lialda from Shire.
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iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16180
Posted 2/11/2020 12:16 PM (GMT -7)
Generally there are two common coatings on the delayed-release mesalamines, these are your pills that are red/brown/orange in color:

1.) Slight variations in the MMX, plastic based coating. These you can touch with wet fingers and nothing happens. They vary slightly among the brands using this coatings on what PH the dissolve starts at which impacts the initial release point, and distribution rate. These are your brand named lialda, apriso, delzicol, and asacol's of the med world. The Zydus generic of Asacol HD also has this MMX coating.

2.) Etha-cellulose based coatings, these absorb water and swell up like grapes. Touch these with wet fingers and you get dye on your fingers, and the pills become slimy. The Zydus Lialda generic does this, as does brandnamed Pentasa.

The extra-credit 3rd options is the protomesalamines like sulfasalazine/colzal that have no coating at all and are a chalky white to slightly yellow in color. Rather they are more complex molecules that gut bacterium break into mesalamine and a byproduct.

I have never handled the Mylan or Sun generic tablets, so I cannot say what they are. I have not handled the generic Apriso, or generic Delzicol tablets either, so cannot say either.
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Dazataz
New Member
Joined : Feb 2020
Posts : 13
Posted 2/11/2020 12:44 PM (GMT -7)
Thanks ipoop and UCnGV.
Dr's and pharmacies should not be able to prescribe/fill these knockoffs that are not the same coating and as such, the medicine isn't delivered to the colon or if it is didn't dissolve for me.
In my peak of UC, the generic ones marked "711" were often seen undissolved in the toilet. I asked doc and he said the med leaches out... BS! I took a wire & poked them to see all the white contents break out. Maybe once I'm in remission and transit time is reduce they might, but why take the chance? Lialda was never seen in my toilet.
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