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Guardian article

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Ulcerative Colitis
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paduk
Regular Member
Joined : Oct 2018
Posts : 54
Posted Yesterday 10:57 AM (GMT -7)
Ulcerative colitis: bacteria findings raise hopes for new treatment
Sufferers found to have low levels of gut microbes that convert bile acids into other substances
https://www.theguardian.com/society/2020/feb/25/ulcerative-colitis-bacteria-findings-raise-hopes-for-new-treatment
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PalaceDan
Regular Member
Joined : Aug 2008
Posts : 51
Posted Yesterday 11:05 AM (GMT -7)
I saw this too. Any of the great minds here have any ideas as to what it might be logical to do if this research is right?
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paduk
Regular Member
Joined : Oct 2018
Posts : 54
Posted Yesterday 11:50 AM (GMT -7)
I am not a great mind by any stretch but maybe one can try to feed this bacteria? Inulin seems to be a good prebiotic for it. I am just speculating...
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iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16180
Posted Yesterday 11:53 AM (GMT -7)
Huh that's a new one on me.

"Certain bacteria in the gut are known to convert bile acids, produced by the liver, into other substances, called secondary bile acids – these substances have recently been suggested to have an anti-inflammatory role."

"The team analysed faeces from patients in each group, finding that patients treated for ulcerative colitis had far lower levels of certain secondary bile acids than the other group. Their faeces contained far less evidence of bacterial genes necessary for the production of these substances.They also had less diverse bacteria in their faeces that the other group, and more specifically, far lower levels of ruminococcaceae. Such bacteria are among those able to convert bile acids to secondary bile acids."

"However, she said it was still unclear if the shift in bacteria and depletion of secondary bile acids were a cause or an effect of such conditions."

The last line is the real-kicker. We know we have wacky bacterium/virus/fungi mixes of intestinal bacterium, lower diversity, more baddies, and less goodies. However, is that a symptom or causative (I believe it is a symptom and others here would say causative).
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Old Mike
Veteran Member
Joined : Jan 2007
Posts : 3927
Posted Yesterday 1:54 PM (GMT -7)
I was going to post the article but see you have it. Cause or effect don't know, or are the secondary bile acid
depleted for a reason. Anyhow here is a possible way, but when I took this stuff I think I got worse. Using quick reply you don't seem to have the option to post live links, oh well.
Oldmike
https://aem.asm.org/content/82/19/5850
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