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Stelara or Humira?

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Ulcerative Colitis
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Posted 2/25/2020 7:26 PM (GMT -6)
Currently faced with a decision of what drug to try next. Tried Entyvio first and that didn’t work for me. Tried Remicade after Entyvio and became allergic to it. I’m leaning towards Stelara because the anaphylactic reaction to Remicade was not fun at all! Any advice is appreciated!
Posted 2/26/2020 7:42 AM (GMT -6)
You have a chance of developing the same reaction to Humira as you had with Remicade because they are both anti-tnf meds. It’s not a certainty but there is a good chance.

Stelara uses a totally different mechanism so if you’re allergic to anti-tnf meds then Stelara is a good alternative biological.
Posted 2/26/2020 7:48 AM (GMT -6)
Humira/remicade/simponi are all sister medications, as you have tried one and failed it then I would skip the rest of those. Go stelara.
Posted 2/26/2020 8:54 AM (GMT -6)
I would definitely do Stelara if I had an allergic reaction to Remicade.
Posted 2/26/2020 1:04 PM (GMT -6)
Ya I think Stelara is the best choice. Plus the less frequent injections are more appealing. At this point I’m not in denial about having to have surgery but I want to exhaust my options before going that route. I don’t want surgery but if it gives me my life back then I’ll take it over being in pain and a prisoner to this disease.
Posted 2/29/2020 7:30 PM (GMT -6)
I hope Stelara does the trick for you. My husband tried Remicade, Humira, Entyvio and none of them worked. Stelara was still in clinical trials and he didn't want to take chance of being on placebo, but GI suggested he try Xeljanz (which as off label at the time). Xeljanz did the trick and still in remission almost 4 years later. And apparently Pfizer is now doing a study on a drug similar to Xeljanz but more targeted to the gut. So you still have a few other options.

Good luck
Posted 2/29/2020 8:03 PM (GMT -6)

suzy-q said...
I hope Stelara does the trick for you. My husband tried Remicade, Humira, Entyvio and none of them worked. Stelara was still in clinical trials and he didn't want to take chance of being on placebo, but GI suggested he try Xeljanz (which as off label at the time). Xeljanz did the trick and still in remission almost 4 years later. And apparently Pfizer is now doing a study on a drug similar to Xeljanz but more targeted to the gut. So you still have a few other options.

Good luck

Did he build up antibodies to Remicade and Humira? I’m worried that will happen to me with Stelara. It seems that my body is quite literally invincible haha.
Posted 2/29/2020 9:55 PM (GMT -6)

smw said...

Did he build up antibodies to Remicade and Humira? I’m worried that will happen to me with Stelara. It seems that my body is quite literally invincible haha.

My GI said that not as many people build antibodies to Stelara. I had to stop Stelara for 6 months because of a surgery. I had no problems restarting Stelara and there were no antibodies detected when I was tested afterwards.
Posted 3/1/2020 6:48 AM (GMT -6)
Oh ok, that’s good to hear. I’m just super scared of having another reaction!
Posted 3/1/2020 7:38 AM (GMT -6)
I ended up with reactions to Remicade, Humira, Simponi and Cimzia. No reaction so far to Stelara.
Posted 3/1/2020 11:54 AM (GMT -6)

ks1905 said...
I ended up with reactions to Remicade, Humira, Simponi and Cimzia. No reaction so far to Stelara.

How long have you been on Stelara? Do you get injections every 8 weeks?
Posted 3/1/2020 9:51 PM (GMT -6)
4 years this month
Posted 3/2/2020 7:18 AM (GMT -6)
90 mgs every 56 days (8 weeks). I restarted with an IV loading dose. Originally I was on the Psoriasis dosing of 45 mgs every 90 days. The psoriasis dosing did not work well for me. I had to stop for 6 months for a surgery
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