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Stelara or Humira?

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Ulcerative Colitis
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smw
Regular Member
Joined : Dec 2015
Posts : 48
Posted 2/25/2020 6:26 PM (GMT -7)
Currently faced with a decision of what drug to try next. Tried Entyvio first and that didn’t work for me. Tried Remicade after Entyvio and became allergic to it. I’m leaning towards Stelara because the anaphylactic reaction to Remicade was not fun at all! Any advice is appreciated!
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ks1905
Veteran Member
Joined : Sep 2005
Posts : 6260
Posted 2/26/2020 6:42 AM (GMT -7)
You have a chance of developing the same reaction to Humira as you had with Remicade because they are both anti-tnf meds. It’s not a certainty but there is a good chance.

Stelara uses a totally different mechanism so if you’re allergic to anti-tnf meds then Stelara is a good alternative biological.
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iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16381
Posted 2/26/2020 6:48 AM (GMT -7)
Humira/remicade/simponi are all sister medications, as you have tried one and failed it then I would skip the rest of those. Go stelara.
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Sara14
Veteran Member
Joined : Mar 2007
Posts : 7217
Posted 2/26/2020 7:54 AM (GMT -7)
I would definitely do Stelara if I had an allergic reaction to Remicade.
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smw
Regular Member
Joined : Dec 2015
Posts : 48
Posted 2/26/2020 12:04 PM (GMT -7)
Ya I think Stelara is the best choice. Plus the less frequent injections are more appealing. At this point I’m not in denial about having to have surgery but I want to exhaust my options before going that route. I don’t want surgery but if it gives me my life back then I’ll take it over being in pain and a prisoner to this disease.
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suzy-q
Regular Member
Joined : Sep 2015
Posts : 264
Posted 2/29/2020 6:30 PM (GMT -7)
I hope Stelara does the trick for you. My husband tried Remicade, Humira, Entyvio and none of them worked. Stelara was still in clinical trials and he didn't want to take chance of being on placebo, but GI suggested he try Xeljanz (which as off label at the time). Xeljanz did the trick and still in remission almost 4 years later. And apparently Pfizer is now doing a study on a drug similar to Xeljanz but more targeted to the gut. So you still have a few other options.

Good luck
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smw
Regular Member
Joined : Dec 2015
Posts : 48
Posted 2/29/2020 7:03 PM (GMT -7)

suzy-q said...
I hope Stelara does the trick for you. My husband tried Remicade, Humira, Entyvio and none of them worked. Stelara was still in clinical trials and he didn't want to take chance of being on placebo, but GI suggested he try Xeljanz (which as off label at the time). Xeljanz did the trick and still in remission almost 4 years later. And apparently Pfizer is now doing a study on a drug similar to Xeljanz but more targeted to the gut. So you still have a few other options.

Good luck

Did he build up antibodies to Remicade and Humira? I’m worried that will happen to me with Stelara. It seems that my body is quite literally invincible haha.
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ks1905
Veteran Member
Joined : Sep 2005
Posts : 6260
Posted 2/29/2020 8:55 PM (GMT -7)

smw said...

Did he build up antibodies to Remicade and Humira? I’m worried that will happen to me with Stelara. It seems that my body is quite literally invincible haha.

My GI said that not as many people build antibodies to Stelara. I had to stop Stelara for 6 months because of a surgery. I had no problems restarting Stelara and there were no antibodies detected when I was tested afterwards.
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smw
Regular Member
Joined : Dec 2015
Posts : 48
Posted 3/1/2020 5:48 AM (GMT -7)
Oh ok, that’s good to hear. I’m just super scared of having another reaction!
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ks1905
Veteran Member
Joined : Sep 2005
Posts : 6260
Posted 3/1/2020 6:38 AM (GMT -7)
I ended up with reactions to Remicade, Humira, Simponi and Cimzia. No reaction so far to Stelara.
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smw
Regular Member
Joined : Dec 2015
Posts : 48
Posted 3/1/2020 10:54 AM (GMT -7)

ks1905 said...
I ended up with reactions to Remicade, Humira, Simponi and Cimzia. No reaction so far to Stelara.

How long have you been on Stelara? Do you get injections every 8 weeks?
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ks1905
Veteran Member
Joined : Sep 2005
Posts : 6260
Posted 3/1/2020 8:51 PM (GMT -7)
4 years this month
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ks1905
Veteran Member
Joined : Sep 2005
Posts : 6260
Posted 3/2/2020 6:18 AM (GMT -7)
90 mgs every 56 days (8 weeks). I restarted with an IV loading dose. Originally I was on the Psoriasis dosing of 45 mgs every 90 days. The psoriasis dosing did not work well for me. I had to stop for 6 months for a surgery
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