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Mesalazine Coronavirus

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Ulcerative Colitis
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alltheway
Regular Member
Joined : Jan 2018
Posts : 34
Posted 3/13/2020 4:25 AM (GMT -6)
Hi everyone,

I have seen a few variations of this same question but just wanted to check if anyone had any specific info. I have had colitis in remission for almost 18 months, but take salofalk tablets and suppositories daily. I live in an area in Europe which has now closed all schools and where there have been numerous cases of coronavirus. I have not been specifically worried about the illness but I am a bit concerned that I might be at a higher risk if I am on immunosuppressants.

What I would like to know is:
a) am I more likely to catch the virus whilst taking the medication
b) is it more likely that I would get complications if I did contract the virus.

I don't want to make anyone panic with this! I am not panicking, but I do live in a place where worrying about coronavirus is no longer paranoia and I'm keen to be prepared best for whatever might happen.

Thanks!
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alltheway
Regular Member
Joined : Jan 2018
Posts : 34
Posted 3/13/2020 5:15 AM (GMT -6)
Somebody else has posted a very useful resource elsewhere which seems to answer my question.

For anyone concerned about any specifics of coronavirus, colitis, and medication, this is the best resource I've seen:

How is coronavirus transmitted?
Via respiratory droplets produced when an infected person sneezes or coughs and can infect people in close contact (within 6 feet). Touching contaminated surfaces before touching your eyes/nose/mouth might also lead to infection.

How does COVID19 compare with seasonal influenza?
Both are infectious respiratory illnesses that present with symptoms such as fever, cough, and shortness of breath. Both can lead to serious illness especially in older people and those with prior medical conditions. One difference is that you can get vaccinated for the flu, but there is not a vaccine available yet for COVID19. Phase 1 studies of a possible vaccine are starting in the next 2 months according to the Centers for Disease Control in the US.

What does this mean for IBD patients?
IBD is a condition of an overactive immune system, and is often treated with immune modification or immune suppression. IBD patients on immunosuppressive medications are in general, more susceptible to infection. Specifically, being on steroids or immune modulators like azathioprine or 6-mercaptopurine or methotrexate can increase an IBD patient’s risk for viral infections. To date, we don’t have specific IBD research on COVID19.

What are the current recommendations for IBD patients related to COVID19?
Many patients have already asked us if they should stop their medications. Medicines such as mesalamine (brand names include Asacol, Apriso, Balsalazide, Lialda, Pentasa) are all safe. It is always a good idea to get off of steroids such as prednisone/prednisilone, if this is possible. Thiopurines (6-mercaptopurine, azathioprine) and tofacitinib tend to inhibit the body’s immune response to viral infections. The thiopurines take months to leave the body. Thus stopping these will not help in the short term. The biologics we currently use to treat IBD such as anti-TNFs (Cimzia, Humira, Remicade, Simponi), ustekinumab (Stelara), vedolizumab (Entyvio) are generally safe. At present we do not recommend stopping these medications. Moreover, the effect of these medications stay in the body, in many cases, for months.

At the current time, we believe it is prudent that IBD patients on immunosuppressants and/or biologics limit unnecessary travel and large gatherings.
The common immunosuppressants and biologics in IBD include prednisone, azathioprine, 6-mercaptopurine, methotrexate, tofacitinib (Xeljanz), infliximab (Remicade and biosimilars to infliximab like Inflectra, Remsima, Renflexis), adalimumab (Humira and biosimilars to adalimumab), certolizumab pegol (Cimzia), golimumab (Simponi), ustekinumab (Stelara), vedolizumab (Entyvio), and natalizumab (Tysabri).

We will keep updating these recommendations as more data become available.

Additional recommendations for everyone:

Avoid being in close contact with sick people.
Wash your hands frequently.
Avoid touching your nose, eyes and mouth.
Seek medical attention in case of fever, cough or difficulty breathing.
If you haven’t, get your flu shot!

FULL SOURCE: https://www.ioibd.org/ioibd-update-on-covid19-for-patients-with-crohns-disease-and-ulcerative-colitis/
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iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16208
Posted 3/13/2020 6:35 AM (GMT -6)
You are not at all immunosuppressed, being on only mesalamine salofalk oral and suppository. So, you you are not at higher risk than the average person of getting CORVID19, and would recover as the average person would. Mesalamine is a 90% topical anti-inflammatory med. That's based on what we know about CORVID19 and IBD.

As far as traveling goes, that's entirely up to you based on what you feel is best given the conditions where you live and where you plan to go. Depends on your risk tolerance, as well (some will say noway, some would say go, and many in between). No absolutely right yes/nos to your question.
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Old Hat
Veteran Member
Joined : Feb 2007
Posts : 5487
Posted 3/17/2020 12:15 PM (GMT -6)
FYI on above list of UC meds: Balsalazide is not a brandname! It's part of the generic name, balsalazide disodium, for brandname Colazal (U.S). / Old Hat (39 yrs with left-sided UC; presently in remission taking brandname Colazal)
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Butterflygirlie
Regular Member
Joined : Apr 2011
Posts : 41
Posted 3/17/2020 6:35 PM (GMT -6)
I got my Remicade infusion last Weds (3/11) I went to the grocery for a few items and worked half a day on Thurs. I’ve been home since (3/12) I personally decided to stay home because after my last Remicade infusion I got the flu for 10 days. I know my body and what has happened in the past after infusions. I’m not one to risk it. I’ve been on Remicade 10 yrs along with Lialda. I’ve been in remission for about a year. I hope everyone stays well.
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Rosiedays
Regular Member
Joined : Jul 2017
Posts : 317
Posted 3/17/2020 9:18 PM (GMT -6)
Just wanted to share this:

https://crohnsandcolitis.ca/Living-with-Crohn-s-Colitis/COVID-19-and-IBD

Also, I’ve heard of reports of people with IBD on 5asa meds who had the virus and got through without hospitalization.
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