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Research: Missing bacteria identified in UC patients

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Ulcerative Colitis
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Casey_LB
Regular Member
Joined : Mar 2015
Posts : 309
Posted 3/19/2020 2:02 PM (GMT -7)
Some promising research:

Secondary bile acids (SBAs) are reduced in UC J-pouch patients vs controls
Reduced Ruminococcaceae bacteria in UC pouches is associated with SBA deficiency
SBA supplementation ameliorates inflammation in animal models of colitis

The study only included patients that previously had surgery (J-pouch), either as a treatment for UC, or as a treatment for "familial adenomatous polyposis" (a non-inflammatory genetic disease), the controls. The UC J-pouch patients had more inflammation (of course), less SBAs and less Ruminococcaceae bacteria.

E.g., it may be that the absence of these "secondary bile acids" and / or the Ruminococcaceae bacteria causes or contributes to UC. And adding these back to patients' guts could be therapeutic.

https://www.news-medical.net/news/20200225/Ulcerative-colitis-and-a-missing-microbe-in-the-gut.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=gastroenterology_newsletter_19_march_2020

Pay for original full paper: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30062-7
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Andreita
Veteran Member
Joined : Aug 2011
Posts : 3828
Posted 3/19/2020 7:37 PM (GMT -7)
Are there supplements for that?
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Casey_LB
Regular Member
Joined : Mar 2015
Posts : 309
Posted 3/19/2020 10:28 PM (GMT -7)
I don't think such supplements are commercially available. In the study, the mice were administered the SBAs rectally.
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