Posted 3/19/2020 3:02 PM (GMT -6)
Some promising research:
Secondary bile acids (SBAs) are reduced in UC J-pouch patients vs controls
Reduced Ruminococcaceae bacteria in UC pouches is associated with SBA deficiency
SBA supplementation ameliorates inflammation in animal models of colitis
The study only included patients that previously had surgery (J-pouch), either as a treatment for UC, or as a treatment for "familial adenomatous polyposis" (a non-inflammatory genetic disease), the controls. The UC J-pouch patients had more inflammation (of course), less SBAs and less Ruminococcaceae bacteria.
E.g., it may be that the absence of these "secondary bile acids" and / or the Ruminococcaceae bacteria causes or contributes to UC. And adding these back to patients' guts could be therapeutic.
Pay for original full paper: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30062-7