Question on Xeljanz

I have been on 5 mg of Xeljanz twice a day now for about a year. I started at 10 mg twice a day and then as symptoms improved, went down to 5 mg maintenance dose. I also recently stopped taking Delzicol per my GI instructions. I was only taking 2 400 mg tablets twice a day and when the prescription ran out, I was told I did not need to refill. this week I'm starting to see some GI issues. Not sure if its a stomach bug or not. I've read alot of success stories about Xeljanz so I'm hoping it hasn't quit working it's magic on me already after a year. Also wondering if stopping Delzicol is having an effect. Would appreciate hearing from others who have experience.

I take 10 mg Xeljanz in a morning and 5 mg in the evening which works for me, as I found that 5 mg each time did not quite hold me. I have been on Xeljanz for 16 months now.

poopydoop said...
In your shoes i would get a calprotectin test. But, my flares are really strongly correlated with calprotectin, which is not the case for everyone. I started to flare 3 months after dropping the dose of xeljanz. The first symptom was abdominal pain but we caught it early because I monitor my calprotectin monthly - it had gone from 30 to 400. I got back into remission quickly using salofalk enemas (4g) which I have not quit since because I don't want to risk another flare. So yes 5ASAs can still make a difference, even on xeljanz.

How do you measure it so frequently?

dsmk said...
My daughter took xeljanz (10 mg) for 9 months then she tapered 5 mg for another 9 months. When she had a flare so she increased her dose to 10 mg and also increased her mesalamine dose 4 tablets per day. After 2 months her flare did not settle. So her doctor switched to entyvio. Hope this will help you

Has the Entyvio helped her?

She had only one infusion. It’s helping a little bit.