"It seems that in individuals with ulcerative colitis, the balance of memory cells is shifted in favor of this rogue population of inflammatory TRM that may become part of the problem by causing persistent inflammation and tissue damage."
"We also found evidence consistent with the possibility that these inflammatory TRM might be exiting the intestinal tissue and entering the blood. Other studies in mice and people have shown that TRM, despite being called “tissue-resident,” can leave tissues in certain circumstances."
"By leaving the tissue and entering the blood, inflammatory TRM may be able to travel to other parts of the body and cause damage. This possibility may explain why autoimmune diseases that start in one organ, like IBD in the digestive tract or psoriasis in the skin, often affect other parts of the body." "
IBD: How a class of killer T cells goes roguehttps://theconversation.com/ibd-how-a-class-of-killer-t-cells-goes-rogue-in-inflammatory-bowel-disease-144176