Posted 8/26/2020 1:43 AM (GMT -6)
So I’ve been on 5mg/kg of remicade since beginning of February after being on humira the previous April - December. Humira worked pretty well - got me to the point of having normal FCP tests etc- but caused me to have issues with itchy skin and then by 6/7 months on it, I had already started to produce some antibodies and it started to lose effectiveness and I went into a small flare (fcp = 100).
I’ve had a similar response to remicade whereby after a few infusions, my stools were formed to the point they were almost too hard if you know what I mean and aggravated a fissure which also wasn’t great. This effect would gradually wear off as I was due my next infusion but then happen again after each infusion. However, I’m now 9 days from my 7th infusion and I’ve noticed with this infusion although my stools are formed, they have not been so hard and I feel like they are going slightly looser again. Still don’t have any blood or mucus and going 1 x a day but I just get this bad feeling. I guess I expect it to fail/get antibodies again.
I’m also 29 weeks pregnant with my first baby so who knows what that’s doing to my bowels....
I still get niggly pains most days which I always link to UC rather than something I ate/being pregnant/IBS etc.
I’m just getting this feeling that because we’re around the same time frame that humira started to fail, that this is going to fail too and I’m dreading going into a flare when I’m about to have my baby.
Any thoughts? I’m also on 25mg mercaptopurine + 100mg allopurinol every other day + 2.4 - 4.8g mesalazine depending on how I feel.