Posted 10/7/2020 6:15 AM (GMT -7)
I've read through experiences with both drugs (Xeljanz vs. Stelara) but haven't seen any comparisons of the two. I was diagnosed with UC in 2009 and had much of my colon removed in an ileorectal anastomosis surgery back in 2010. I still have residual inflammation in my rectum (proctitis) but no bleeding. Normal day for me is about 3-5 BMs per day with varying urgency but when I flare up, that can increase.
My proctitis has been stubborn, and suppositories like Canasa and Uceris steroid foam have not really helped. Having taken mesalamines in the past when I had full-blown UC, I found those were unhelpful, so I'm considering a biologic.
Are the safety profiles and side effects for Xeljanz and Stelara relatively similar? Anyone know if one would be more inclined to work for rectal inflammation? As a matter of convenience, Stelara is more appealing since the maintenance does is just one injection every 8 weeks vs a pill twice a day, but other than that, I do not have a good baseline for comparing safety and efficacy, especially for someone in my situation with proctitis.
Any insight/recommendations would be helpful.
Thank you in advance.
35 years old, male
Diagnosed with UC in 2009
Surgery (ileorectal anastomosis) in 2010
Active rectal inflammation