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OT Covid vaccine

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Ulcerative Colitis
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CCinPA
Veteran Member
Joined : Dec 2014
Posts : 1573
Posted 11/18/2020 5:26 AM (GMT -7)
Does anyone know if the current leading vaccines in the U.S. (Pfizer & Moderna) are live vaccines? Those of us on biologics aren't supposed to have live vaccines so I have been wondering
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ambling
Veteran Member
Joined : Feb 2011
Posts : 1039
Posted 11/18/2020 6:28 AM (GMT -7)
The leading ones are genetically engineered RNA, having instructions to make a protein which prompts an immune response (so the immune system learns how to kill the virus.) Nothing live. Extremely clever as it doesn't involve handling the virus at all.

Should be very safe.
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IamCurious
Veteran Member
Joined : Jan 2010
Posts : 3556
Posted 11/18/2020 7:02 AM (GMT -7)
I hope it is safe but I would err on the side of caution. For one thing in this rush for approval there have been no long term safety studies.

Another thing that worries me is that the former vice president of Pfizer, who was also its chief science officer, has serious reservations about Pfizer's vaccine. I will not be among the first to volunteer for it.

https://www.thelibertybeacon.com/top-pfizer-whistleblower-trashes-companys-vaccine-breakthrough-spin/

https://thehuntingtonian.com/2020/10/06/chief-science-officer-for-pfizer-says-second-wave-faked-on-false-positive-covid-tests-pandemic-is-over/
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Serenity Now
Veteran Member
Joined : Jan 2009
Posts : 2401
Posted 11/18/2020 8:05 AM (GMT -7)
I won't be the first to volunteer either... but how long would you say it would be wise to wait re "long term safety studies". I worry about the long term safety too, but OTH I don't want to isolate inside my house forever while the rest of the world goes on. So I am in a dilemma about this.
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Michelejc
Forum Moderator
Joined : Jan 2011
Posts : 2584
Posted 11/18/2020 9:06 AM (GMT -7)
I don't think I'll be getting the vaccine right away. I do get the flu shot every year but that's been around for centuries. I don't trust this vaccine yet.
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ambling
Veteran Member
Joined : Feb 2011
Posts : 1039
Posted 11/18/2020 11:34 AM (GMT -7)
As usual we have IAC spreading utter nonsense. The Liberty Beacon is a far-right conspiracy and pseudoscience website, and should not be taken as a reputable source.

It saddens me that misinformation and conspiracy theories still abound.
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IamCurious
Veteran Member
Joined : Jan 2010
Posts : 3556
Posted 11/18/2020 1:10 PM (GMT -7)
Ambling,

There is no nonsense and pseudoscience here. If you don't like The Liberty Beacon as a source then you can google Dr. Michael Yeadon for yourself and you will see dozens of sources verifying that he was the former Vice President and Chief Science Officer for Pfizer.

And you will also find that he is going public with his serious reservations about Pfizer's COVID-19 vaccine, and that he indeed wrote that open letter to Mike Hancock who is the Secretary of State for Health and Social Care of United Kingdom.
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CCinPA
Veteran Member
Joined : Dec 2014
Posts : 1573
Posted 11/18/2020 4:18 PM (GMT -7)
Iam -- that dr you mention hasn't worked at Pfizer for 9 years. I don't know why all the hospitals are getting overrun with false positive Covid patients ;) You lurk in some very questionable places online

ambling -- that is good news about the vaccine. Sounds like it will be safe for us.

I am like the others here ... gonna wait and see what happens for a while. I know the first Pfizer announcement said 90% effective but when I looked into it it was 90% for 7 days after the 2nd dose. I don't know how long their 2nd announcement covers and I didn't look up Moderna's info. I want to know much longer results and it's just too soon right now. I am a bit concerned about Pfizer's vaccine. Their CEO sold $5.6 million of his stock the day they put out that first press release. At the risk of feeding Iam's conspiracy theories (lol) I have to say that just sounded fishy to me.
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garyi
Veteran Member
Joined : Jun 2017
Posts : 2091
Posted 11/18/2020 4:23 PM (GMT -7)
Healthy skepticism is one thing, but.....

The Pfizer and Moderna mRNA vaccines are going through large, detailed and transparent clinical trials, including sub groups, liked seniors, and cancer victims. While armchair epidemiologists, naysayers, and political cynics abound, we need the coming vaccines as soon as practical. Only Novavax and GSK/Sanofi are developing more conventional (flu like-protein) vaccines. mRNA and viral vaccines hold much more promise.

At best, the USA, and probably Europe, will be able to vacinnate 25 million people a month, so we're looking at late 2021, at best, for meaningful coverage. Maybe 80% when those who have already had the virus and are immune (?) are included. Distribution, storage, double dosage, handling, and IT tracking of both the vaccine, and those vaccinated, costs, are just some of the challenges facing us. Protection for the rest of the world will take even longer, well into 2022.

Questions about the durability of efficacy, long term safety, illness or just symptomatic prevention, and how many are willing to take the vaccine remain unanswered. So, don't throw your masks away, don't make plans for quick globetrotting, or think things will be "back to normal" anytime soon. The FDA, unlike most mass media and extreme website muckrakers, is working FOR us. Like with Ulcerative Colitis, it's incumbent on us to do our own serious and ongoing research.

I plan to be first in line for an FDA approved vaccine, right after medical folks, and first responders. Good luck and prayers, everyone.
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ambling
Veteran Member
Joined : Feb 2011
Posts : 1039
Posted 11/18/2020 4:48 PM (GMT -7)
IAC, you happily go down the rabbit holes of the internet to dig up obscure nonsense.

Thankfully, most see through it.
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momto2boys
Veteran Member
Joined : Jun 2013
Posts : 2361
Posted 11/18/2020 4:49 PM (GMT -7)
I had an appointment with my PCP today and she said no live virus in any of the current vaccines in development. The issue with the Pfizer one is that it has to be kept in deep freeze which limits who can distribute it, the average medical practice won't be able to keep it cold enough. Moderna's is more likely to make it to the average doctor's office because it is more stable. She said the word on the street is that this vaccine won't make it to average patients for quite some time, so we should have more data by the time it will be available to the general population.
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poopydoop
Veteran Member
Joined : Dec 2018
Posts : 927
Posted 11/18/2020 4:50 PM (GMT -7)
I guess you have to weigh up if you're more scared of covid or a covid vaccine. I know which one I'd choose.
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iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16197
Posted 11/18/2020 7:34 PM (GMT -7)
I'll gladly take the vaccine when approved. I could breath a heck of a lot easier knowing I had some decent immunity. Pfizer's vaccine was developed in Germany, not the mad rush in the usa that's missing all safety concerns.

If you're against vaccines then you don't have to take them, or can wait a while if desired.

I know there's a smaller subset who'd never take a vaccine, unless some impossibly, ridiculous, extra amount of unclearly defined testing was done to meet their demands. Nothing new, a boring conversation repeated over the decades here lol.
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Jane974
Regular Member
Joined : Feb 2017
Posts : 418
Posted 11/18/2020 8:16 PM (GMT -7)
I'm also open to taking a vaccine once i look at the data. I will likely wait to see how people with autoimmune issues react since the vaccine is generally tested on a healthy population.

If it's safe and allows us to socialize, go to work and not be overly worried about getting sick, then the pros outweigh any cons by a large margin.
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poopydoop
Veteran Member
Joined : Dec 2018
Posts : 927
Posted 11/19/2020 12:55 AM (GMT -7)
I'm already taking a drug for which the long term effects are unknown (xeljanz) so I can't apply one set of logic to that and other to a vaccine.

Also, long covid scares me. Women in their 40s seem to be most at risk and I'm nearly 40. Have 2 friends who got long covid and it has been quite debilitating for them.
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UCinGV
Regular Member
Joined : Mar 2007
Posts : 499
Posted 11/19/2020 6:59 AM (GMT -7)
I'll take it if Dr Fauci says it's safe.
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CCinPA
Veteran Member
Joined : Dec 2014
Posts : 1573
Posted 11/19/2020 4:17 PM (GMT -7)
I am not anti vax at all. Got my flu shot a couple weeks ago. The Covid vaccine was rushed, but by the time it's widely available a lot more will be known about it. If it's still safe in the spring/summer I will get it. Hope my reservations about Pfizer are unwarranted, but my spidey sense says something is amiss with that one.
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Jane974
Regular Member
Joined : Feb 2017
Posts : 418
Posted 11/19/2020 5:34 PM (GMT -7)
CCinPA, in regards to conspiracy theories about Pfizer, all execs of fortune 500 companies have little control over when their stock is sold and must follow very stringent regulations. They often pre-sell way in advance due to regulation and to avoid insider trading accusations (this is called a 10b5-1 plan). They have very short, discrete periods of when they can sell stock since they have insider information; employees of fortune 500 companies also have discrete periods of when they can sell. For example, the exec would specify often 6 month to 1 year in advance when they want to sell stock and fill out the paperwork with their company way in advance, sometimes 1 year ahead of schedule. So if he sold stock in September 2020, the order was often put in around September 2019 (or sometime far off enough). In the press, it looks like they just sold the stock and appears fishy, but the order was put in months before. The media ignores this information because it's not a sexy story that captures headlines.

Post Edited (Jane974) : 11/19/2020 5:39:11 PM (GMT-7)

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Old Hat
Veteran Member
Joined : Feb 2007
Posts : 5456
Posted 11/19/2020 8:41 PM (GMT -7)
Let's find out what COVID-19 vaccine Dr. Fauci takes himself and recommends. I was a kid when the Salk polio vaccine 1st came to production/mass distribution, and he had injected his own sons with it beforehand. / Old Hat
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IamCurious
Veteran Member
Joined : Jan 2010
Posts : 3556
Posted 11/20/2020 5:06 AM (GMT -7)
all execs of fortune 500 companies have little control over when their stock is sold and must follow very stringent regulations

That misses the point. Pfizer CEO Albert Bourla planned to sell his stock back in August, but the company itself decided when to announce its good news. Trumpers are still complaining that Pfizer and the FDA knew the good news about the vaccine much earlier but decided to wait until after the election to make a public announcement.

I dunno if that is true but I don't think it would be too hard for Pfizer to schedule their announcement before the stock sale rather than a day after the sale. Besides this doesn't answer the question why would someone sell the vast majority of his company's stock if he truly believed in its long term future..

Post Edited (IamCurious) : 11/20/2020 5:14:24 AM (GMT-7)

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ambling
Veteran Member
Joined : Feb 2011
Posts : 1039
Posted 11/20/2020 6:24 AM (GMT -7)
Groan, no that isn't what happened.

The reason the shares got sold is because they reached a predetermined price.
Months earlier, as permitted and regularly done by executives, he (and others) set a price at which they would accept a sale of part of their shares. When the market hit that price, it triggered the sale of the shares.
If the shares hadn't reached the predetermined price then they would not have been sold. Nothing at all to do with any special timing of an announcement.

Yes, he would have known that the data on their trial was coming out around November, and he would have hoped it was positive. So what. No weird coincidence, and no conspiracy, just business.
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Jane974
Regular Member
Joined : Feb 2017
Posts : 418
Posted 11/20/2020 5:36 PM (GMT -7)

IamCurious said...
br />
I dunno if that is true but I don't think it would be too hard for Pfizer to schedule their announcement before the stock sale rather than a day after the sale. Besides this doesn't answer the question why would someone sell the vast majority of his company's stock if he truly believed in its long term future..

Pfizer's CEO nets $20 million in comp per year at least so over a period of several years, he has more than 100 million in stock options. The fact that he sold $5 million is less than 5% of total shares he owns most likely, and less than 5% of his net worth. Rich people diversify and move money around all the time. This is not meaningful and is only 5% of his total stock value or so. The media just likes good headlines, but doesn't ever give you the context. https://www.fiercepharma.com/pharma/pfizer-new-boss-bourla-nets-17-9m-2019-pay-as-drugmaker-beat-all-financial-targets
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IamCurious
Veteran Member
Joined : Jan 2010
Posts : 3556
Posted 11/20/2020 6:40 PM (GMT -7)
https://markets.businessinsider.com/news/stocks/pfizer-ceo-sold-stock-6-million-30-percent-compensation-vaccine-2020-11-1029798146
"The Pfizer chief cashed out more than 60% of his stock the same day, raking in $5.6 million — about 30% of his total compensation in 2019"
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chocotofu
Regular Member
Joined : Aug 2019
Posts : 35
Posted 11/22/2020 1:35 PM (GMT -7)
I'm a woo-woo person who has been skeptical of vaccines and spent a long time trying to manage my UC without pharmaceuticals. Didn't work. I ended up in the hospital. I almost died. I'll take the vaccine. Just like I'm going to take biologics. Biologics also have horrible potential side effects. The benefits outweigh the risks. Same as with the vaccine.

Also... Those sources posted are not real news outlets. They are hyper-biased far-right propaganda sites.
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Jane974
Regular Member
Joined : Feb 2017
Posts : 418
Posted 11/22/2020 6:17 PM (GMT -7)
The data on covid and IBD (over 3000 people so far) is a bit alarming in terms of the percentage who are hospitalized, 21% total, given that the population tends to be younger overall. It's even high if you are in remission, but higher with inflammation and age. It seems like IBDers are faring worse in terms of hospitalizations at least so far. Death rate as 2% doesn't seem way higher than normal population, but still concerning. I'm more inclined to take a vaccine after looking at this.
https://covidibd.org/current-data/
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