Jane, are you asking because you have a long history of UC treatment with mesalamines? I know from my own experience that it's possible to suddenly "top-out" of Rowasa, which happened to me after 14 yrs of successful intermittent use. My gastroenterologist has sub-specialized in IBD treatment since 1980s, and wasn't particularly surprised when it turned on me, causing gnawing left-sided pain. I needed to stop using it. Thankfully, brandname Colazal controlled my UC afterward, but I could not tolerate Apriso (fewer caps daily but strong respiratory side effects). UCers are known to have heterogeneity in response to Rx meds; that's why many MDs can't really help us when things go wrong. If you're near any medical school experts, it's a good idea to inquire about
their possibilities for consultation. The reliable ones won't push you onto immunosuppressants, if that worries you, nor will they brush you off for reporting exceptional symptoms like SFN. / Old Hat (40 yrs with left-sided UC; in remission taking Colazal)
Post Edited (Old Hat) : 12/26/2020 12:00:04 AM (GMT-7)