Suppositories with Amino Acids that strengthen the mucosa lining

I found some very interesting suppositories on Amazon - they have essential amino acids including threonine. There have been many people on this forum who have had varying levels of success with whey protein, different amino acids, and there have been UC published studies on threonine, proline, serine, and cysteine and how effective they are in rebuilding the mucin of the mucosa in the colon. I am not going to put the name of the product and company here since it might break rules but I have used this company's glutathione suppositories in the past for my ulcerative colitis - it was kind of a mixed result - but there was some impact for sure. In my case, my rectum and sigmoid colon have the worst inflammation. I have had success with whey protein, glycine, threonine orally but what do people think of an amino acid suppository that includes threonine delivered rectally through a suppository? Would it be a better mechanism of delivery since it would go STRAIGHT to the inflammation instead of having to go through the entire GI tract before getting to the colon?

typo! Thanks! Any thoughts on the topic?

quincy said...
It's gi tract, not track.
q

Unfortunately those amino acids don't go straight to the area.
They will get absorbed into the blood stream, and are then used by the body in the normal way. It's probably better to simply eat more complete protein.

Are you sure that is the case? I believe there is also absorption by the intestines. For example, in a previous thread one of the posters on this forum said that eating lobster helped her a lot and later discovered through experiments that the key was the threonine level in the lobster. My understanding is that the food provides the nutrients to the lining via digestion and having foods high in amino acids (that are healthy for the lining) are delivered directly to the lining through the food.

Even if this were not to be the case, and if most of the amino acid does go straight into the blood, it would still have to go through the liver. Hence, I think the benefit of a suppository delivery would deliver more of the amino acid.

ambling said...
Unfortunately those amino acids don't go straight to the area.
They will get absorbed into the blood stream, and are then used by the body in the normal way. It's probably better to simply eat more complete protein.

But I am talking about free-form amino acid suppositories and NOT protein complex suppositories. Of coures proteins have to be broken down but this is not proteins in the suppositories. Its free form amino acids. Therefore, there is no breakdown needed, there are no peptide bonds needed to broken down into smaller peptide bonds. See what I am saying? The suppository product that I am looking at is already in its pure broken down form of a free amino acid so it should be readily absorbable.

ambling said...
Yeah I'm sure.

Digestion of protein is complex. Gastric juices begin the breakdown, then pancreatic and intestinal enzymes continue to break down the peptide bonds into smaller peptide bonds, and then finally free amino acids. That happens along the way through the small intestine (mostly the upper small intestine).
The large intestine can absorb water and some minerals, but it cannot breakdown whole protein. It isn't designed for that.

A couple of grams of free amino acids (not a lot) delivered via suppository, could be absorbed into the blood stream and circulate. It isn't like topical medications such as steroid or mesalamine enemas.

bad mood? Well, certainly, you are not the authority of whether it will or will not be absorbed straight to the area. But thank you for your response and your opinion.

ambling said...
That's what I said....
" A couple of grams of free amino acids (not a lot) delivered via suppository, could be absorbed into the blood stream and circulate. It isn't like topical medications such as steroid or mesalamine enemas. "

I already explained in an earlier post that they will not go straight to the area.

And I also addressed your remark about lobster, by explaining protein digestion, ok?

Yes poopydoop, that is exactly the case.

Not sure why you need to be so rude IBD girl?
I am, in fact, an authority in this case.

I'll avoid helping you if you prefer.
Take care

well i know this - in most ulcerative colitis patients (at least definitely mine as per my biopsy of the intestinal wall), the inflammation causes injury to the crypts and the goblet cells. In my colonoscopy and biopsy, it was described that the crypts and the goblet cells were damaged. Below I have included an excerpt on the function of the goblet cells. Given that these cells are responsible for nutrient digestion and utilize amino acids to create mucin glycoproteins, I am hypothesizing that a more direct delivery to these goblet cells could be more ideal.

Goblet cells are a type of intestinal mucosal epithelial cell, which serves as the primary site for nutrient digestion and mucosal absorption. The primary function of goblet cells is to synthesize and secrete mucus. As the primary secretory cell in the superficial epithelium of large airways, goblet cells secrete mucin glycoproteins, which are the major macromolecular components of mucus. Different types of goblet cells can be identified based on location and function.

Yeah, my background.

The small intestine handles nutrient digestion. The large bowel mostly absorbs water and a few minerals. Since UC affects the large bowel, protein digestion and absorption should not be an issue.

Goblet cells in the large bowel mostly secrete mucus.