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Gut microbiota reflect disease severity in COVID-19

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Ulcerative Colitis
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Casey_LB
Regular Member
Joined : Mar 2015
Posts : 298
Posted 1/15/2021 2:19 PM (GMT -7)
Well, this doesn't sound good...

From BMJ Gut, a journal of the British Society of Gastroenterology

https://gut.bmj.com/content/early/2021/01/04/gutjnl-2020-323020?int_source=wisepops&int_medium=wisepops&int_campaign=usage

“We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus.”

“Gut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals irrespective of whether patients had received medication (p<0.01). Several gut commensals with known immunomodulatory potential such as Faecalibacterium prausnitzii, Eubacterium rectale and bifidobacteria were underrepresented in patients and remained low in samples collected up to 30 days after disease resolution. Moreover, this perturbed composition exhibited stratification with disease severity concordant with elevated concentrations of inflammatory cytokines and blood markers such as C reactive protein, lactate dehydrogenase, aspartate aminotransferase and gamma-glutamyl transferase.”

“Associations between gut microbiota composition, levels of cytokines and inflammatory markers in patients with COVID-19 suggest that the gut microbiome is involved in the magnitude of COVID-19 severity possibly via modulating host immune responses. Furthermore, the gut microbiota dysbiosis after disease resolution could contribute to persistent symptoms, highlighting a need to understand how gut microorganisms are involved in inflammation and COVID-19.”
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*Jen*
Veteran Member
Joined : Jul 2005
Posts : 609
Posted 1/30/2021 5:48 PM (GMT -7)
Interesting. Early on people in here had Covid and reported they did not have serious cases. I came back on to check in and see if that had changed. Is there a recent thread?
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