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When you see pathogenesis and IBD in pubmed

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Ulcerative Colitis
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iPoop
Forum Moderator
Joined : Aug 2012
Posts : 16374
Posted 3/1/2021 7:31 PM (GMT -6)
Obviously no cure yet, but happy when I see articles talking about pathogenesis.

"MicroRNAs overexpressed in Crohn’s disease and their interactions with mechanisms of epigenetic regulation explain novel aspects of Crohn’s disease pathogenesis"

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7890887/

Background
In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's disease (CD) affected tissues, with the aim to determine their impact in the pathogenesis and evolution of the disease.

Conclusion
The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD.
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