Sounds like MAP isn't the only smart, immune and antibiotic resistant strain that could be causational. McMaster-led team unlocks possible Crohn’s disease triggerhttps://brighterworld.mcmaster.ca/articles/mcmaster-led-team-unlocks-possible-crohns-disease-trigger/
Investigator Brian Coombes said his team identified a strain of adherent-invasive E-coli (AIEC) that is strongly implicated in the condition and is often found in the intestines of people with Crohn’s disease.
“If you examine the gut lining of patients with Crohn’s disease, you will find that around 70 to 80 per cent of them test positive for AIEC bacteria, but one of the things we don’t understand is why,” said Coombes, professor and chair of the Department of Biochemistry and Biomedical Sciences, and the Canada Research Chair in Infectious Disease Pathogenesis.
“We believe that AIEC is a potential trigger of Crohn’s disease.”
AIEC bacteria grow in a biofilm that coats cells lining the intestinal wall, protecting them from both the immune system and antibiotics. The team identified a critical protein structure on the surface of the bacteria that lets them grow in biofilms.