Symptoms not improving

Hello.
I’ve been dealing with a flare up for almost a month now. I had a doctor appointment a little over 2 weeks ago. Before that appointment I had been taking mesalamine suppository 1x a day for maintenance (I had on been on a maintenance dose for about a month before I experienced a flare up again). The doctor now has me on mesalamine suppository and Balsalazide 750 mg 4 capsules in the morning. At night I take a hydrocortisone enema. Since my dr appointment my symptoms have gotten much worse. I visit the restroom probably 20 times a day and it wakes me up multiple times a night. I don’t have a bowel movement every time. Sometimes it’s just blood or mucus other times it’s just gas. The urgency is much worse than I’ve ever experienced. She ordered blood tests and they were all normal except my hemoglobin was slightly low and my Calprotectin was 71. My next appointment isn’t until the 27th. Should I try to get in earlier? She said the enema could take 2 weeks to work. But it has only gotten worse. Also I’m curious what the next reasonable step will be. She mentioned that I might eventually start Humaira if this doesn’t work. Should I try something else first?

I would call my doctor. That's a lot of bathroom trips, plus the nightly trips and blood aren't fun. I'm dealing with similar and had to go back on prednisone. You could try mesalamine enemas instead of the steroid enemas or an oral steroid, like nssg mentioned. I hope you get to feeling better ASAP.

Also possible to be having an allergic reaction to a higher dose of mesalamine. If you've only done 1 gram suppositories, added oral balsalazide, and now have increased frequency and urgency then that could be a calling-card to it. Given, only 5 percent of patients experience allergic reactions to mesalamine.

An allergic reaction to mesalamine is described as a dramatic worsening of bowel symptoms.

Try skipping the otal balsalazide for 48 hours and see if you dramatically improve.

Quincy - I have been checked for C diff and different things before but not the most recent tests.