Posted 5/26/2021 6:33 AM (GMT -7)
The way the antibodies work is that they neutralize the drug. In the beginning, you'll have a small number of antibodies, so the drug still lasts but maybe not as long. Over time, there are so many antibodies that the drug doesn't work, and you have to switch drugs.
There are a few strategies that doctors use to deal with this:
1) Increase the dose of the drug so that there is more of it in your body, which means more time before the antibodies neutralize it.
2) Decrease the interval, so instead of getting it, say, every 2 months, you get it every month.
3) Add another drug to suppress the immune system.
It seems like your doctor is doing #1. He is increasing the dose. Sometimes increasing the dose makes the UC go away and the body backs off.