The sulfa component in sulfasalazine does not cleave into mesalamine! Mesalamine was bonded to sulfa decades back so that the resulting oral 5-ASA combo med would reach the colon without being metabolized en route there!!!!! Therefore, sulfasalazine is NOT an appropriate replacement for Lialda! It's cheaper because it's basically an antiquated mesalamine compound that mainly helps patients with arthritic complications. Sulfasalazine should only be taken in the enteric-coated tablets because it's hard on the stomach, can adversely affect the taste of food, and can cause photosensitivity to eyes and skin. (Been there & done that when it was the only option to steroid meds!) *** The whole issue of insurance companies refusing to pay for the most helpful mesalamine meds [meaning, the ones with the least side effects] is an absolute outrage that gastroenterologists and patients should be fighting together!!!!!! / Old Hat (40+ yrs with left-sided UC; in remission taking Colazal) *** P.S. Sulfa and sulfites are not synonyms; sulfasalazine contains SULFA, not sulfites which are preservative substances used in liquids & some solid foods.
Post Edited (Old Hat) : 9/8/2021 7:58:20 PM (GMT-6)