2006BM, one thing worth mentioning is that going up a rung in the drugs ladder doesn't necessarily mean that you're moving onto a drug with more risk and side effects. There's the cost to be considered, in that drugs higher up the ladder cost more.
On the NHS you used to have to fail on Aza / 6MP before you could try biologics, due to cost, not safety. This was a problem for me as I knew someone in my family had major side effects from Aza, but I wasn't allowed to try a biologic till I'd failed on them. Fortunately it seems to have changed now.
EDIT - I think I skimmed the part where you say you're planning to get pregnant again. Has your GI advised that Simponi is the safest option during pregnancy? I'd Google but I'm at work right now!
Post Edited (UCyousee) : 11/24/2021 4:25:21 AM (GMT-7)