From the article:
Humira was linked to 169,000 reported serious adverse events and 13,000 reports of deaths, followed by Enbrel with 135,000 serious events and 8,000 deaths. Yet neither is among the top 20 prescribed medications in America, according to IQVIA data.
Remicade, the drug Tschannen was taking, had 98,000 reports of serious adverse events, including 6,000 reports of deaths, the analysis found.
Beginning in the early 2000s there was a spike in sepsis cases among people with rheumatoid arthritis. A 2018 paper by researchers at Boston University School of Medicine found that hospitalizations for sepsis more than tripled between 1993 and 2013.
The big uptick seemed to occur beginning in about 2002 when the number jumped from 4,700 cases to 2013, when there were 32,000 cases.
However, the increases coincided with the rise of biologic drugs. In the period between 1999 and 2002, three popular biologics — Remicade (1999), Enbrel (2000) and Humira (2002) — were approved to treat rheumatoid arthritis.
What's important is: if you're on biologics, and you develop a fever, get seen ASAP.