But the FDA is super careful, much more so than European equivalents.
I am in Europe. Our regulatory bodies are super careful too! Only we don't have "black box warnings" full stop. Just lists of side effects and their frequency. When I started to flare a couple of years ago on xeljanz, my GI was saving increasing my xeljanz dose as a last resort if nothing else worked, because of the blood clot issue, which they are taking very seriously. Managed to fix it with enemas at the time.
Answer to your other question. I am doing fine, now 3.5 years on xeljanz. But need to check my calprotectin as I've been having more abdominal pain than usual, which can sometimes be the start of a flare (or sometimes nothing).
I have terrible fatigue but I think that was the case before I started xeljanz.
Happy to hear you are mostly still doing great. It would be nice to see comparative studies of xeljanz and rinvoq, I guess that will take a while.