Van Jordan

?

Mark4623 said...
R-Lipoic Acid won't make it passed the acids in the stomach. Besides, the form that Pravda speaks about is Dihydrolipoc Acid (DHLA) which nobody manufactures anymore, and hasn't for a while. If you are going to take a lipoic supplement, I think the one you are looking for is Alpha-Lipoic Acid.

This is incorrect. ALA has an acidic PH. The dihydro form is even more acidic. They definitely make it past the stomach, especially if take it with a fatty meal.

R-ALA is not appropriate for UC patients. It is the oxidized form and will cause a worsening of UC. I can also back up that statement with personal experience. Within days of taking ALA, my UC flares.

R-DHLA is probably different and is why Dr. Pravda used it in his experimental enema, but I haven't been able to find any to try.

DO NOT take R-ALA (also known as ALA). It is not good for UC patients.

I have flax seed on my cereal but I'm struggling to work out I'd it's ala, r-ala or other. I think it's ala so I may give it up for a while. It's hard to tell if some things help or hinder sometimes.

other question: what do you think selenium, Mn and Cu? these can help to SOD to decrease ROS? but these supplement bad to colitis?

Post Edited (Hambo88) : 8/7/2022 5:25:13 AM (GMT-7)

Hambo88 said...
this thing connect to ROS.
my blood result was very good last time this after me and my wife went to a bycicle ride... the sport make me always flare... but this after it made very bad flare....

What do you think if i do sport always a little, and slowly increase the amount then it can be help a little?
I think if i increase gradually the amount of sport my body reaction will be better... or not...?
nowadays i did not do any sport because it causes flare to me..

other question: what do you think selenium, Mn and Cu? these can help to SOD to decrease ROS? but these supplement bad to colitis?

Mild to moderate exercise can benefit most UC patients. Heavy exercise increases injury (i.e. heavy weight lifting) which increases oxidative stress. You should start slow and mild and gradually increase. If you start getting bowel symptoms, you should stop at that level of intensity and never go higher than that.

Heavy exercise has also been shown to temporarily restrict blood flow to the abdominal organs. This is because heavy exercise shifts the body's blood flow burden to the muscoskeletal system and away from the organs. In UC this can be detrimental because it will slow healing.

As for vitamins and minerals... most vitamins and minerals on the market are garbage. They are synthetic and oxidized forms. If you can find naturally derived vitamins then they will be safer. Selenium, manganese and magnesium are generally safe because they are reliable antioxidants. Copper and zinc are more complicated because in UC the ratio is usually highly skewed toward one or the other being in excess, so you need to be careful with those.

Mineral derangement is common in UC because we tend to be chronically malnourished and we lose a lot of bodily resources to bleeding and inflammation. I get my mineral levels tested by blood every 6 months and then adjust my intake accordingly.

VanJordan said...
I get my mineral levels tested by blood every 6 months and then adjust my intake accordingly.

Same here. Extensive blood work twice a year for vitamins, minerals, triclycerides, PSA, homocysteine, etc.

VanJordan said...
most vitamins and minerals on the market are garbage. They are synthetic and oxidized forms. If you can find naturally derived vitamins then they will be safer.

Maybe.
But a good case can be made that bad reactions to supplements, whether they are derived naturally or not, could be from excipients added such as maltodextrin, polysorbates, Carboxymethylcellulose, stearates, etc.

IamCurious said...
Maybe.
But a good case can be made that bad reactions to supplements, whether they are derived naturally or not, could be from excipients added such as maltodextrin, polysorbates, Carboxymethylcellulose, stearates, etc.

Hard to know for sure without more studies, but my hunch is no. Now that I am in remission thanks to antioxidants I don't react to any of those things. I would say they are aggravating factors but they don't cause UC. Rubbing maltodextrin, polysorbate, methylcelluloses and stearates onto a wound is bound to make the wound worse... but I doubt they are causing the wound, unless they are contributing somehow to oxidation.

Conversely, if I take synthetic vitamins, my inflammation status noticeably increases.

Studying biochemistry has been a real eye opener for me. The way that most of the vitamins and minerals are made in the supplement industry is appalling. Many are industrial byproducts that are transformed through addition, substitution and elimination reactions to make organic analogues. They think that because they are structurally identical to the natural forms that they can replace them, but we know from effect on the body that it's not true. I am yet to talk to a biochemist who can explain this difference.

For example, in an organic chemistry class I synthesized menthol, the key volatile found in peppermint oil. Everyone who smelled it agreed you would think it's peppermint, but that it doesn't smell quite like it. Yet it is structurally identical to the real deal, so who cares right? Except real peppermint oil doesn't give me migraines.

I take very few vitamins and minerals these days, just key ones. The rest I get from food. I think the way science currently looks at organic molecules is somehow an incomplete picture. You can't just take petrol-derived hydrocarbons, reconfigure them, and say that you have the same menthol as what came out of a peppermint plant. They are two different beasts, but medically/legally they are not.

I think part of the issue in this discussion is that we have different definitions of "root cause". When excess H2O2 is a result of some trigger, I would consider that trigger to be closer to the root cause than the H2O2. Otherwise it's a bit like saying "inflammation is the root cause of UC".

CCinPA said...
Van Jordan -- when you say you are in remission is that because you are symptom free or have you had a scope to confirm? Also, how long have you been in remission? I may have missed it, but how did you determine your genetic deficiency?

Thanks

I don't get scopes because they cause flares. I used a pill camera. I am also in remission according to lack of symptoms, blood work, lifestyle adjustments, and other factors such as complete absence of food allergies, I absorb iron again without IVs, etc. My doctors concur.

Hambo88 said...
Van JOrdan: Please, how can I identify that an antioxidan - forexample quercitin - if is oxidized form in the current brand ? or this brand contain reduced form of quercitin? how can i know this? or c vitamin or any antioxidant?
And please give me the dosage(mg/bodyweight/) the antioxidants what are you taking. Thank you

When an antioxidant is recommended (i.e. quercetin), you don't need to worry about if you are getting the oxidized form or not. Because it's an anti-oxidant, it can't be oxidized. What I was referring to was a lot of vitamins and minerals on the market.

As for dosage... I do not go by body weight. Despite the fact that H2O2 is damaging the body, it exists only in micromolar (ug) quantities, so it doesn't require a lot to anti-oxidize it. Also, most of these supplements are food sourced so the body will urinate out any excesses. The only exception is sulforaphane, it seems to disagree with UCers if taken at full dose right away. From my own experience, I believe it's because it's doing something to the gut bacteria. Some research I've read on sulforaphane indicates it has a profound positive impact on the gut microbiome, and if you take high doses to start with, the shift may be too sudden.

Quercetin - 250mg once daily
Grapeseed extract - 400mg daily
Curcumin (phytosomal/mervia) - 500mg twice daily
Sulforaphane - 20mg daily (start small and increase gradually)
Vitamin C (naturally sourced as camu) - 1000mg daily. Acerola cherry and rosehip are another good source. Do not use synthetic ascorbic acid as it does not appear as effective for this problem (I tried).
Rutin - 100mg daily

Van Jordan -- how long have you been in remission? How did you determine your genetic deficiency?

CCinPA said...
Van Jordan -- how long have you been in remission? How did you determine your genetic deficiency?

Since March of this year.

I plugged my raw 23andme data into a generator that could list all my detox and methylation SNPs. Then I focused on the ones responsible for the enzymes that antioxidize H2O2 and discovered they are all recessive.

Mark4623 said...
VJ
Since we are on antioxidant supplements. Have you heard of Astaxanthin, and tried it or not? From what I read it is a powerhouse antioxidant stronger than vitamins C, and E. What is your thoughts on this supplement.

Thanks

As mentioned previously... there are probably many different antioxidants that have benefits. If research shows they are powerful reducing agents, then they're worth trying. Since astaxanthin is a carotenoid - a pigment used by plants to mitigate oxidative stress caused by UV - it would probably help. Rutin is another pigment.

Plant pigments in general are natural antioxidants which is why there are so many in this protocol. I think astaxanthin is worth trying, as is any natural plant pigment... such as the blue from blueberries or the red from cherries (these are called anthocyanins). In particular, fruits that ripen in full sunlight are going to have high antioxidant content. The trouble is that you need to ingest them at high enough concentration to make a difference, otherwise just eating fruit would fix UC. Hence supplements.