Van Jordan/Dr. Pravda (antioxidant method

we had a discussion in the main topic which is created earlier, but i think would be very good if we could collect the expereiences who started this method.
Maybe we could see how effective it for different people, becuase OK this way was very good to Van Jordan, he is in remission, but i would be very very wonder for other people experiences..

I beginn with myself.

I take grape seed 400 mg, sulforazana 2 mg, quercitin 500 mg for approx. 40 days.
I did not achieve remmission but blood result was better then before, but maybe it is because of prednisone supppository which i have used it for a short period becuase my GI prescribed it for my lower inflamination.

If the improving keeps going in future , and i see my next blood result will be better than i think it will be the effect of the antioxidant. My next blood check will be around begining of october, we see....

Maybe what is your opinion, these amount of antioxidant is too less? (c vit and camu t cause me bowel irriration, not the best to me)
What do you think Can we take Zinc?

Please share your expereneices if you do this/or similar method.

thank you

@VanJordan You've been talking about sun exposure before. I also have the feeling that too much sun exposure worsens my symptoms. But doesn't the science says the opposite and promotes sun bathing for UC patients? I'm kind of confused on this one.

Pinocchio said...
@VanJordan You've been talking about sun exposure before. I also have the feeling that too much sun exposure worsens my symptoms. But doesn't the science says the opposite and promotes sun bathing for UC patients? I'm kind of confused on this one.

UV increases the superoxide problem at the end of the electron transport chain. UV splits oxygen quite readily. That leads to more hydrogen peroxide production. I have noticed the same thing over the years. I love summer time and some sun helps with vitamin D production, but if I get an actual sunburn I start flaring. The antioxidants help with that.

Vitamin D is a type of weak steroid so it suppresses inflammation. That's why the body produces it in sunlight, it's a type of cellular protection from sun damage, kind of like how plants produce carotenoids for the same reason. We then evolved a means to convert this protection into a type of vitamin that the body can use for other functions.

So a little bit of sun helps natural vitamin D but too much increases the oxidation problem.

Thankyou Van Jordan. We’re still
Listening. So far I’ve only added the grape seed and sulforaphane but within days I noticed a difference. The grape seed has saved me from pred when my GI messed up my dosages for entyvio. I hope you’ll be able to share Dr Pravdas report when it’s released as I’m unable to find it. Does he post it to you tube? I will also post results once I start using the butyrate enemas

@VanJordan.
Could you please let us know which contents of supplements are not what we’re looking for in these. Mainly popular substitutes for the actual ingredient we need.

Im having a lot of trouble shipping any of the brand supplements you mentioned from abroad to Spain so I need to find alternative brands but don’t want to end up buying junk.

Thanks

Hi Hambo88,

In response to your question. Here is a list of supplements that I am currently trying/using in my arsenal:

Camu Camu capsules 1000mg/day
Curcumin capsules 3200mg/day
Qing Dai capsules 2000mg/day
Tributyrin-X gelcaps 6/day
Metamucil Fiber capsules 5 caps 3xday
Probiotic blend 2/day
Also just ordered some c60 carbon gelcaps to try as an antioxidant.

I used to have light blood in my stools with diarrhea, and now the diarrhea is pretty much gone, and haven't had any blood in my stools for over three months now. I assume that since there is no more blood it means that my ulcers are healing. Or at least that is what I am guessing.

Any comments, or constructive criticism would be welcome, as we are all here for information.

Thanks

I have tried these supplements for a long time. The idea of anti oxidant and UC is not a new idea and definitely not solely related to this Dr Pravda guy. All such supplements did for me was make my IBS really bad and do nothing for my UC. So much for oxidative stress being the root cause of UC.

Antioxidant theory is also discussed on the other forums....esp in GERD and IBS....very few people get any meaningful results from these protocols there.

kyle_dn said...
I have tried these supplements for a long time. The idea of anti oxidant and UC is not a new idea and definitely not solely related to this Dr Pravda guy. All such supplements did for me was make my IBS really bad and do nothing for my UC. So much for oxidative stress being the root cause of UC.

Antioxidant theory is also discussed on the other forums....esp in GERD and IBS....very few people get any meaningful results from these protocols there.

Pravda didn't invent oxidative stress theory, but he discovered that the root cause of UC is hydrogen peroxide.

Which antioxidants did you try, at what doses, and for how long?

waxmoth said...
All the supplements mentioned are available in Europe. Getting diet right first is probably more important and dosage then needs to be worked out in mg/kg based on available science. Many good naturopathic doctors will be able to do this if needed. I get products based on no/minimum excipients that don’t have a therapeutic purpose. Not sure if it is permitted to mention sources/products so I won’t for the moment.

Has there been any consideration of DMSO as an antioxidant? It is not something I use but it seems to be a possible candidate should things go South. It may also be a possible delivery vehicle for specific antimicrobials to help with bacterial/fungal biofilms.

DMSO is great for many things but it's an aprotic solvent so it doesn't release protons. In other words it has no pH. Therefore it has no activity against hydrogen peroxide.

I agree with you that diet should come first. If the diet is mostly processed food or other junk, then adding supplements will have reduced benefit.

CCinPA said...
has anyone achieved symptomatic remission yet using this protocol? I know it's only been a few months that this has been talked about here, but Van said it worked for him in a month.

I have maintained remission most of the time for the past 14 years by watching my diet and taking supplements that have worked for me. I am not familiar with Dr. Pravda's protocol but I see that I am already taking many of the supplements he recommends.

Here is a partial list of studies published in NIH's PubMed showing how some non-pharmaceutical supplements show efficacy against IBD. So it wouldn't surprise me at all if there exists a natural, alternative protocol that might achieve symptomatic remission.

http://www.ncbi.nlm.nih.gov/pubmed/25830661
"In ulcerative colitis, aloe vera gel, triticum aestivum, andrographis paniculata extract and topical Xilei-san were superior to placebo in inducing remission or clinical response, and curcumin was superior to placebo in maintaining remission; boswellia serrata gum resin and plantago ovata seeds were as effective as mesalazine,
In Crohn's disease, mastic gum, Artemisia absinthium, and Tripterygium wilfordii were superior to placebo in inducing remission and preventing clinical postoperative recurrence, respectively. Herbal therapies exert their therapeutic benefit by different mechanisms including immune regulation, antioxidant activity, inhibition of leukotriene B4 and nuclear factor-kappa B, and antiplatelet activity.
Large, double-blind clinical studies assessing the most commonly used natural substances should urgently be conducted."

http://www.ncbi.nlm.nih.gov/pubmed/1312317
CONCLUSIONS: Four months of diet supplementation with fish oil in patients with inflammatory bowel disease resulted in reductions in rectal dialysate leukotriene B4 levels, improvements in histologic findings, and weight gain

https://www.ncbi.nlm.nih.gov/pubmed/25724700
"Conclusions: Addition of curcumin to mesalamine therapy was superior to the combination of placebo and mesalamine in inducing clinical and endoscopic remission in patients with mild-to-moderate active UC, producing no apparent adverse effects."

/www.ncbi.nlm.nih.gov/pmc/articles/PMC1856764/
"Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes."

https://pulse.seattlechildrens.org/novel-diet-therapy-helps-children-with-crohns-disease-and-ulcerative-colitis-reach-remission/
“In a first-of-its-kind-study led by Suskind, published today in the Journal of Clinical Gastroenterology, diet alone was shown to bring pediatric patients with active Crohn’s and UC into clinical remission.”

Post Edited (IamCurious) : 8/14/2022 3:44:39 PM (GMT-7)

poopydoop said...
In other words all the stuff about supplements being more restricted in europe is complete and utter nonsense.

Thank you for sharing that BROQ was and is still available in France. However I have a friend who lives in France and she says that vitamins and alternatives are much more restricted in Europe. She needed to get a doctor to write a prescription for her to take extra vitamin D.

IamCurious said...
I have maintained remission most of the time for the past 14 years by watching my diet and taking supplements that have worked for me. I am not familiar with Dr. Pravda's protocol but I see that I am already taking many of the supplements he recommends.

Here is a partial list of studies published in NIH's PubMed showing how some non-pharmaceutical supplements show efficacy against IBD. So it wouldn't surprise me at all if there exists a natural, alternative protocol that might achieve symptomatic remission.

Dr. Pravda doesn't recommend any supplements, just FYI. This protocol is one that I came up with, based on his research and experimenting on myself. It is a work in progress.

The stuff mentioned in the study you cited, I have tried all of it, and although it downgraded my UC (especially boswellia, andrographis and curcumin), it wasn't enough. For the 10% of UC patients that are totally refractory, only strong antioxidants work. Most of the things cited in that study are anti-inflammatories but not anti-oxidants. Anti-inflammatories suppress the immune system but they don't resolve the hydrogen peroxide problem.

However, it's good that some research is being done on supplements. I notice a lot of research getting really close to the truth but kind of near-missing. Once you know that hydrogen peroxide is the key, you everything starts to make sense.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710726/

Vanjordan - have you ever tried NAC?