Van Jordan/Dr. Pravda (antioxidant method

greenuc said...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710726/

Vanjordan - have you ever tried NAC?

Not in a long time. Taking NAC pushes glutathione production, but that glutathione then needs to be reduced in order to deal with hydrogen peroxide. In people with UC whose reducing capacity is still half decent, this strategy might work. For myself, NAC made me unwell. It felt strangely similar to taking resveratrol or ALA (the oxidized version), so I think maybe it was driving oxidation somehow. A researcher I spoke to said that it might've been detoxing heavy metals because it's a thiol compound, but I'm not so sure. My over all concern about NAC is that it's unnatural since that amino acid normally exists in balance with all the other amino acids. Then suddenly you're taking a large quantity of it.

That's all to say... you can try adding it, but it's not part of the protocol I use.

ok I'm was in 5years of remission and started to flare couple of weeks back. I'm always keep an eye on alternative medicine as well but only try them when I flare because does not want to ruin anything while in remission. I was aware of RO theory long time back. Old Mike has discussed this here in number of threads. So now I had a flare, I've decided to give a go.. I have included grape seed extract and sulpharophane and also upgraded the usual medicine. I felt alot of increased air in my colon but the systems are controlled, so I'm ok with it. My only concern is my period was about 7 days early, this rarely happens to me. I know curcumin can be a blood thinner and culturally we strictly avoid turmeric during pregnancy. I would like to get information from any female followers of these protocol.


In the meantime another recent research on anti oxidant therapy .Researchers designed a silicon-based agent that successfully generated hydrogen continuously in the mouse gastrointestinal tract in an ulcerative colitis (UC) model. The hydrogen served as an antioxidant that could eliminate the reactive oxygen species shown to induce the chronic inflammation responsible for the damage and symptoms caused by UC.

https://www.sciencedaily.com/releases/2022/07/220725105652.htm

Another way to get butyric acid in the colon could be Tributyrin which is an ester composed of butyric acid and glycerol.

There is a product called Tributyrin-X which is coated to only release in the colon. I've never taken it though so can't vouch for it.

greenuc said...
Another way to get butyric acid in the colon could be Tributyrin which is an ester composed of butyric acid and glycerol.

There is a product called Tributyrin-X which is coated to only release in the colon. I've never taken it though so can't vouch for it.

sweety5 said...
ok I'm was in 5years of remission and started to flare couple of weeks back. I'm always keep an eye on alternative medicine as well but only try them when I flare because does not want to ruin anything while in remission. I was aware of RO theory long time back. Old Mike has discussed this here in number of threads. So now I had a flare, I've decided to give a go.. I have included grape seed extract and sulpharophane and also upgraded the usual medicine. I felt alot of increased air in my colon but the systems are controlled, so I'm ok with it. My only concern is my period was about 7 days early, this rarely happens to me. I know curcumin can be a blood thinner and culturally we strictly avoid turmeric during pregnancy. I would like to get information from any female followers of these protocol.


In the meantime another recent research on anti oxidant therapy .Researchers designed a silicon-based agent that successfully generated hydrogen continuously in the mouse gastrointestinal tract in an ulcerative colitis (UC) model. The hydrogen served as an antioxidant that could eliminate the reactive oxygen species shown to induce the chronic inflammation responsible for the damage and symptoms caused by UC.

https://www.sciencedaily.com/releases/2022/07/220725105652.htm

I can't really give you medical advice about your period as I'm not a doctor, but curcumin can definitely thin blood so maybe that had something to do with it. Sulforaphane should be started slowly. I take 20mg but I started with 1/5 of that by breaking open the pill and splitting it up.

The research you showed is interesting but I feel these newfangled methods are unnecessary. Natural antioxidants work, we just need to know the right ones. We don't need silicone hydrogen-delivering technology.

greenuc said...
@Vanjordan

From: Sustained Histologic Remission (Complete Mucosal Healing) 12 Years after One-Time Treatment of Refractory Ulcerative Colitis with Novel Combination Therapy: A Case Report
"The treatment consisted of a combination enema (5-aminosalicylic acid, budesonide, sodium butyrate, and sodium cromoglicate) administered simultaneously with a systemic oral reducing agent (alpha lipoic acid)."

I know ALA was discussed in the other thread. Do we know if Pravda used ALA or DHLA? Is DHLA even available in supplement form, I have not been able to find it.

It is probably DHLA. ALA seems to make UC worse, I can attest to that. You're right though, there's no DHLA on the market, even by custom compounding. I haven't been able to find it. So I don't know if DHLA is important or not. It seems that other antioxidants work too so maybe it doesn't matter.

Mark4623 said...
This is an email I received from GeroNova when I asked if they carried DHLA capsules.

Hi Mark,
Thanks for your interest in our products.
It's in the works but won't be available until late this year or early next.
When we have it ready, it will be available on our website.

Please check in again at the end of the year.

Best,
Sitara
GeroNova

Hope this helps!

Thanks for posting this Mark. And yes, please let us know how Tributyrin-X works for you.

What is yoir opinion why does camu
cause bowel problem(make more bm/light diarrhea)?

I try to get bio available c vitamin therefore i bought came but this not ok to my bowel.

Vitamin E mentioned in the discussion was not something I had used unless it is naturally present in one of the interventions. I did a bit of reading to see what would be the best supplement and it appears that delta Tocotrienol may be more effective for UC than alpha Tocopherol which seems to be the most common form ( the former is more easily absorbed by the gut mucosa).

https://www.jstage.jst.go.jp/article/jnsv/65/4/65_318/_article/-char/ja/

There is also some recent research showing that a lactic acid bacterium, L. cremoris which was already known to attenuate UC symptoms works synergistically with a metabolite of Tocotrienol. I have found one European source, in Italy, of L. cremoris in a probiotic called Abinol.

https://www.researchgate.net/publication/361292615_Delta-tocotrienol_13'-Carboxychromanol_a_Vitamin_E_Metabolite_Interacts_With_Gut_Microbes_As_Indicated_by_Its_Anti-colitis_Synergy_With_a_Lactic_Acid_Bacterium_in_Mice

Yes that's it. Just got a message from his facebook page stating this.

I just received the notification. I'll be reading the paper carefully and making comments later. It will take me at least several hours to comb through the preliminaries, and days to have a full grasp.

Please ignore the troll above. There's no way he could have thoroughly read the paper in the couple of hours between the link being posted and his reply. Do not feed the troll.

The fact that the mods let this kind of behaviour run amok on these forums, with their only strategy being to shut down whole discussions, is a black mark on this forum. Without real consequences to offenders, combined with the mod team's one-solution to every problem, it means that valuable discourse can't possibly take place here.

To those interested in civilized conversation, in addition to the threads we're struggling to maintain here, I'm going to be creating an off-site chat group through Google Groups where we can talk interrupted by trolls. It's very clear that the mods here support this behaviour by their lack of action, which calls into question who is running these forums.

I'll let you all know once the outside group is ready. Cheers.

My two cents: I don't think one or two papers will ever "prove" anything. What is more likely to happen is some other researcher will see this and think "Hmm, maybe there's a nugget here to work with" and try their own study... and so on and so on. That's how any medical treatment is arrived at, one little stepping stone at a time.

Oh I see that very concept has been mentioned above, as a quote from the paper: "...is worthy of continued and expanded research to confirm a potential causal role in the pathogenesis of this debilitating inflammatory bowel disease affecting millions worldwide."

That's a worthwhile finding.