OK, well its good you only had AIN 1. I am 99% sure it was the upadacitinib that is the root cause of my AIN. I had annual scopes for most of the past 20 years and I never had dysplasia before. It was only after I started upadacitinib that the problems started. The condylomas (external) appeared. Loads of them. And even with multi treatment strategies, they would not go. Then AIN 2 got diagnosed after 2 years on upada. Now in Year 3, it progressed to AIN 3. I was never on Pred during these years....
Also, my Dr told me that he has several patients on immune suppression and all of them have complained about
condylomas. As for JAK inhibitors, well, they are too new a drug for any proper research as their effect on HPV. We can only really go by personal experience I guess. In time, the link will be recognised though.
You are right the risk of anal cancer is small in the general population, but it is much greater in people with IBD/Lowered immunity/High risk HPV strains/Persistent infection. I fall into all 4 categories.
Post Edited (barnsbury) : 11/17/2022 4:37:46 AM (GMT-8)