You don't have to do prednisone if you don't want to. There are other options. Budesonide for example.
Prednisone ruined my spine and I will not take it unless it's an absolute emergency.
Budesonide has never had an effect on me. Years ago I took oral Uceris, with no effect, and then Entorcort, which did help. Of course, Entocort has been discontinued by the manufacturer, or so I learned when I tried to get an Rx filled a couple of months ago.
Even though I've had UC for almost 30 years, I never had to take Pred until just about
a year ago. Moving from Hawaii has not been good for my UC.
@Quincy - I've always taken enemas in the evening as I'm getting ready for bed. Daily BMs ~4-6, good day is 3, but the worst symptom right now is the urgency. And yes, as I noted I am indeed flaring. It's a good suggestion to use the steroid foam enema during the day and mesalamine enema at night. I still have some Uceris foam. But sheesh - all these medications, and I was so hopeful that Remicade would help. Started Infliximab in April, insurance switched to Remicade after the three initial doses of Infliximab (?!), second maint dose was this week. Still holding out hope...