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A Plant-Based Option to Treat Ulcerative Colitis

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Ulcerative Colitis
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Posted 1/20/2023 2:09 PM (GMT -8)
New data presented during Crohn’s and Colitis Congress 2023 in Denver suggest an herbal compound curcumin and QingDai outperformed placebo to induce clinical response and remission in patients with ulcerative colitis. - https://www.hcplive.com/view/plant-based-option-treat-ulcerative-colitis
Posted 1/20/2023 3:16 PM (GMT -8)
This says the study was 10 patients, and 3 reached remission. If that would hold for wide scale use it's about the same success rate as most drugs so might be worth a try if you have mild disease.
Posted 1/20/2023 9:38 PM (GMT -8)
Let us know how it works for you.

q
Posted 1/21/2023 10:15 AM (GMT -8)
It would be nice to see a follow-up beyond 16 weeks.
Posted 1/22/2023 3:08 AM (GMT -8)

CCinPA said...
This says the study was 10 patients

Researchers conducted a two-part trial in 59 patients with active UC. The second was a placebo-controlled trial conducted at two centers in Israel and Greece, in which 42 patients were randomly assigned 2:1 to receive enteric-coated Curcumin / QingDai (3 g/day) or placebo for 8 weeks. Patients who responded continued curcumin or placebo alone for an additional 8 weeks as maintenance.

CCinPA said...
3 reached remission.

The primary outcome of clinical and endoscopic or biomarker response was met during the induction phase, achieved in 43% patients vs. only 8% with placebo. Additionally, endoscopic improvement (75%) and clinical remission (50%) rates were statistically significantly better compared with placebo. These rates are notable for being achieved in a difficult-to-treat population, as half of the patients were biologic or immunomodulators failures. Taken together with the placebo-controlled trial results, this definitely paves the way toward incorporation of this botanical approach as an add-on strategy in patients with active UC,” he said. - https://www.healio.com/news/gastroenterology/20230120/curcuminqingdai-induces-remission-in-active-uc-paves-the-way-for-integration-in-care
Posted 2/23/2023 4:31 PM (GMT -8)
These studies were by the Sheba Medical Centre in Israel. And they have a company Evinature selling the supplements.

Im from Australia and I have been in the middle of a bad flare. I took their survey and ordered the supplements, which arrived 4 days ago. There is different ratios of QD and Curcumin in each bottle.

So 4 days in and I have had all bleeding and mucus stop.
Diarrhoea and urgency still happening, and I'm still up in the night. I will keep going for the full 6 weeks and see how we go.

Really hoping this is the real deal.
Posted 2/23/2023 5:22 PM (GMT -8)
Aussie -- keep us posted on how you are doing.
Posted 2/26/2023 3:13 PM (GMT -8)
I will do. Still not much change.

I'm meant to be on Imuran but haven't started it as I wanted to give this a good shot on its own. Previously on mesalamine for 1.5yrs which worked until it really didn't. Have been on Prednisone twice before but weaned off that and, of course, symptoms returned.
Haven't really talked to my GI about this stuff, but seeing him again in 2 weeks. Don't think he will approve of what I'm doing.

Post Edited (AussieJ) : 2/26/2023 3:17:44 PM (GMT-8)

Posted 2/26/2023 8:42 PM (GMT -8)
What mesalamine exactly that didnt work anymore?
q
Posted 2/27/2023 6:42 PM (GMT -8)
Salofalk 3g/day
Posted 2/27/2023 8:31 PM (GMT -8)
It probably didn't work, so to say, because you weren't on rectal mesalamine enemas (my suggestion rather than the suppositories) as well.

q
Posted 3/1/2023 6:03 PM (GMT -8)
I've just ordered some Evinature as well (from Australia too!). I filled in the survey and it advised to order Protocol RED. I'll report back on my progress once I get them.

Background: I've had a UC flare for over two years and latest results showed Mayo 3 level inflammation. I've been on Entyvio since last November with not much result and have now been changed to 4 weekly. Also taking 4 Mezavant tablets a day. Flare seemed to coincide with start of Covid vaccinations - I've had 4 in total - but may be just pure coincidence. I'd previously only ever had mild flares for a couple of days, maybe once every 6 months at the most.
Posted 3/6/2023 11:59 AM (GMT -8)
I'm currently megadosing curcumin to see if it can induce remission. If it works, I'll post back.
Posted 3/14/2023 8:15 PM (GMT -8)
First week completed on Evinature Protocol RED. I think I'm starting to see an improvement - but nothing dramatic. No blood this week and reduced mucus. Last night I only had to get up once during the night instead of multiple times... the best night for a long time! (my Apple watch said almost 8 hours of sleep instead of the usual 6-ish) My poop seems to be a little more 'formed'. There also seems to be a longer time period between toilet stops - and therefore less frequency. But there is still urgency when the time arrives! There's still a long way to go before I would say I'm back to 'normal' but it's looking promising so far. Hopefully, it continues to improve.
Posted 3/15/2023 2:03 AM (GMT -8)
I have gotten very into TCM the past year or so and have read a lot of great things about Qing Dai. I do not think I would take it without guidance from a TCM doctor but that is just me. After so many years of doing natural methods, it never amounted into anything positive for me so I am always hesitant now. I am curious if it can give you guys remission. You might try qigong along with it just for some gentle movement and balancing of your energy channels. I do it every morning!
Posted 3/15/2023 4:48 AM (GMT -8)

Medz said...
an herbal compound curcumin and QingDai outperformed placebo to induce clinical response and remission in patients with ulcerative colitis.
42 patients were randomly assigned 2:1 to receive enteric-coated Curcumin / QingDai (3 g/day)

Is it possible to get some enteric-coated curcumin /QingDai ?
Posted 3/20/2023 3:00 PM (GMT -8)
Second week almost completed on Evinature. Definitely less frequent toilet stops. Managed a 5km run on the weekend without a stop for the first time in a year! (there was a time where I had to stop almost every km) Yesterday I went almost 24 hours without a toilet stop. Major milestone!! I have a colonoscopy coming up in April so it will be interesting to see the results from that.
Posted 3/21/2023 1:58 PM (GMT -8)
Sounds like you are going in the right direction, Aussie. What all are you taking now? You mentioned several things in your posts. The problem with trying several things at the same time is that you won't know what is actually helping. You mentioned that you recently changed Entyvio to every 4 weeks ... how many 4 week infusions have you had?
Posted 3/21/2023 2:12 PM (GMT -8)
I've had 3 x 4 weekly infusions so far - the first infusion was end of November. Entyvio + Mezavant (been on 4 tablets a day for a year) is the current medication. There hadn't been much of a change in symptoms until the week I started Evinature.
Posted 3/21/2023 2:22 PM (GMT -8)
Hope it continues to work and you reach the promised land of Remission!!
Posted 3/21/2023 3:16 PM (GMT -8)

CCinPA said...
The problem with trying several things at the same time is that you won't know what is actually helping.

I've struggled with this so many times over the years. When in a flare I throw everything I can muster at it...when things calm down, it's difficult to know exactly what has worked. The scientific method be damned, I just want to get better!

For instance, I started Remicade almost a year ago. At around 29 weeks of no improvement I was ready to give up, as was my GI. Oddly, at the same time I developed pain that sent me to the ER. Its cause was never determined, but my GI suggested Prilosec should it happen again. It did happen again, I took a 14-day course of Prilosec, my pain disappeared, but as importantly, so did my flare, to the point where am I as "normal" as I can reasonably expect to be.

Remicade finally worked? Prilosec changed my PH so that mesalamine released more effectively? Environmental? I don't know, but I keep a pack of Prilosec around, and continue my Remicade.

To make matters even more muddy, I was on QD for around a month just prior to the aforementioned pain (hence the nexus to this thread). I stopped it when the pain started, just because I wasn't sure if it was at fault. But maybe it had something to do with my symptom improvement?
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